TY - JOUR
T1 - Ischemia and Reperfusion Injury in Kidney Transplantation
T2 - Relevant Mechanisms in Injury and Repair
AU - Nieuwenhuijs-Moeke, Gertrude J
AU - Pischke, Søren E
AU - Berger, Stefan P
AU - Sanders, Jan Stephan F
AU - Pol, Robert A
AU - Struys, Michel M R F
AU - Ploeg, Rutger J
AU - Leuvenink, Henri G D
PY - 2020/1/17
Y1 - 2020/1/17
N2 - Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.
AB - Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.
KW - ischemia reperfusion injury
KW - kidney transplantation
KW - delayed graft function
KW - innate immune system
KW - adaptive immune system
KW - apoptosis
KW - necrosis
KW - hypoxic inducible factor
KW - endothelial dysfunction
KW - REGULATORY T-CELLS
KW - HYPOXIA-INDUCIBLE FACTOR-1-ALPHA
KW - ANTIBODY-MEDIATED REJECTION
KW - DELAYED GRAFT FUNCTION
KW - MESENCHYMAL TRANSITION
KW - RECEPTOR 4
KW - IMMUNE-RESPONSES
KW - DENDRITIC CELLS
KW - INNATE IMMUNITY
KW - IN-VIVO
U2 - 10.3390/jcm9010253
DO - 10.3390/jcm9010253
M3 - Review article
C2 - 31963521
SN - 2077-0383
VL - 9
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 1
M1 - 253
ER -