Isocyanide-Based Multicomponent Reactions of Free Phenylboronic Acids

Constantinos G. Neochoritis, Tryfon Zarganes-Tzitzikas, Michaela Novotna, Tatiana Mitrikova, Zefeng Wang, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Domling*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)


Boronic acids are amongst the most useful synthetic intermediates, frequently used by modern drug design. However, their access and fast synthesis of libraries are often problematic. We present a methodology on the synthesis of drug-like scaffolds via IMCRs with unprotected phenylboronic acids. To demonstrate an application of our approach, we also performed one-pot Suzuki couplings on the primary MCR scaffolds. Moreover, we performed a thorough data-mining of the Cambridge Structural Database, revealing interesting geometrical features.

Originele taal-2English
Pagina's (van-tot)6132-6137
Aantal pagina's6
TijdschriftEuropean Journal of Organic Chemistry
Nummer van het tijdschrift35
StatusPublished - 22-sep-2019

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