Kinetic Resolution and Stereoselective Synthesis of 3-Substituted Aspartic Acids by Using Engineered Methylaspartate Ammonia Lyases

Hans Raj, Wiktor Szymanski, Jandré de Villiers, Vinod Puthan Veetil, Wim J. Quax, Keiko Shimamoto, Dick B. Janssen, Ben L. Feringa, Gerrit J. Poelarends*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

11 Citaten (Scopus)

Samenvatting

Kinetic resolution and asymmetric synthesis of various valuable 3-substituted aspartic acids, which were obtained in fair to good yields with diastereomeric ratio values of up to >98:2 and enantiomeric excess values of up to >99 %, by using engineered methylaspartate ammonia lyases are described. These biocatalytic methodologies for the selective preparation of aspartic acid derivatives appear to be attractive alternatives for existing chemical methods.
Originele taal-2English
Pagina's (van-tot)11148-11152
Aantal pagina's5
TijdschriftChemistry
Volume19
Nummer van het tijdschrift34
DOI's
StatusPublished - 19-aug-2013

Citeer dit