L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents: The TRAILS study

Esther Nederhof; Hanneke E. Creemers; Anja C. Huizink; Johan Ormel; Albertine J. Oldehinkel

doi:10.1016/j.neuropsychologia.2011.02.019

L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents: The TRAILS study

Esther Nederhof^*, Hanneke E. Creemers, Anja C. Huizink, Johan Ormel, Albertine J. Oldehinkel

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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The purpose of the present study was to investigate whether a length polymorphism in the dopamine receptor D4 gene (DRD4) was associated with approach related traits in adolescents. Data were used from TRAILS (TRacking Adolescents' Individual Lives Survey), a population based cohort of Dutch adolescents. Sensation seeking, assessed with personality questionnaires from the participants themselves and their biological father and mother (n=1282) was not associated with DRD4 genotype. Gambling performance (n=591) and startle reactivity (n=432) were not associated with DRD4 genotype either. Explanations for the dissociation might be sought in differences in development of the limbic system and the prefrontal cortex, both with high dopamine receptor D4 densities and both involved in approach related behaviours

Originele taal-2	English
Pagina's (van-tot)	1359-1362
Aantal pagina's	4
Tijdschrift	Neuropsychologia
Volume	49
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1016/j.neuropsychologia.2011.02.019
Status	Published - apr.-2011

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title = "L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents: The TRAILS study",

abstract = "The purpose of the present study was to investigate whether a length polymorphism in the dopamine receptor D4 gene (DRD4) was associated with approach related traits in adolescents. Data were used from TRAILS (TRacking Adolescents' Individual Lives Survey), a population based cohort of Dutch adolescents. Sensation seeking, assessed with personality questionnaires from the participants themselves and their biological father and mother (n=1282) was not associated with DRD4 genotype. Gambling performance (n=591) and startle reactivity (n=432) were not associated with DRD4 genotype either. Explanations for the dissociation might be sought in differences in development of the limbic system and the prefrontal cortex, both with high dopamine receptor D4 densities and both involved in approach related behaviours",

keywords = "Novelty seeking, High Intensity Pleasure, Temperament, Emotional processing, Bangor gambling task, Iowa gambling task, Affective startle modulation, Startle amplitude, Various number tandem repeat (VNTR), NOVELTY SEEKING, RECEPTOR, MODULATION, CHILDREN, EMOTION, REFLEX, GENE",

author = "Esther Nederhof and Creemers, {Hanneke E.} and Huizink, {Anja C.} and Johan Ormel and Oldehinkel, {Albertine J.}",

year = "2011",

month = apr,

doi = "10.1016/j.neuropsychologia.2011.02.019",

language = "English",

volume = "49",

pages = "1359--1362",

journal = "Neuropsychologia",

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T1 - L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents

T2 - The TRAILS study

AU - Nederhof, Esther

AU - Creemers, Hanneke E.

AU - Huizink, Anja C.

AU - Ormel, Johan

AU - Oldehinkel, Albertine J.

PY - 2011/4

Y1 - 2011/4

N2 - The purpose of the present study was to investigate whether a length polymorphism in the dopamine receptor D4 gene (DRD4) was associated with approach related traits in adolescents. Data were used from TRAILS (TRacking Adolescents' Individual Lives Survey), a population based cohort of Dutch adolescents. Sensation seeking, assessed with personality questionnaires from the participants themselves and their biological father and mother (n=1282) was not associated with DRD4 genotype. Gambling performance (n=591) and startle reactivity (n=432) were not associated with DRD4 genotype either. Explanations for the dissociation might be sought in differences in development of the limbic system and the prefrontal cortex, both with high dopamine receptor D4 densities and both involved in approach related behaviours

AB - The purpose of the present study was to investigate whether a length polymorphism in the dopamine receptor D4 gene (DRD4) was associated with approach related traits in adolescents. Data were used from TRAILS (TRacking Adolescents' Individual Lives Survey), a population based cohort of Dutch adolescents. Sensation seeking, assessed with personality questionnaires from the participants themselves and their biological father and mother (n=1282) was not associated with DRD4 genotype. Gambling performance (n=591) and startle reactivity (n=432) were not associated with DRD4 genotype either. Explanations for the dissociation might be sought in differences in development of the limbic system and the prefrontal cortex, both with high dopamine receptor D4 densities and both involved in approach related behaviours

KW - Novelty seeking

KW - High Intensity Pleasure

KW - Temperament

KW - Emotional processing

KW - Bangor gambling task

KW - Iowa gambling task

KW - Affective startle modulation

KW - Startle amplitude

KW - Various number tandem repeat (VNTR)

KW - NOVELTY SEEKING

KW - RECEPTOR

KW - MODULATION

KW - CHILDREN

KW - EMOTION

KW - REFLEX

KW - GENE

U2 - 10.1016/j.neuropsychologia.2011.02.019

DO - 10.1016/j.neuropsychologia.2011.02.019

M3 - Article

SN - 0028-3932

VL - 49

SP - 1359

EP - 1362

JO - Neuropsychologia

JF - Neuropsychologia

IS - 5

ER -

L-DRD4 genotype not associated with sensation seeking, gambling performance and startle reactivity in adolescents: The TRAILS study

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