L-serine synthesis in the central nervous system: a review on serine deficiency disorders

L Tabatabaie, L W Klomp, R Berger, T J de Koning

Onderzoeksoutputpeer review

159 Citaten (Scopus)

Samenvatting

The de novo synthesis of the amino acid L-serine plays an essential role in the development and functioning of the central nervous system (CNS). L-serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and L-serine derived lipids. Patients with congenital defects in the L-serine synthesizing enzymes present with severe neurological abnormalities and underscore the importance of this synthetic pathway. In this review, we will discuss the cellular functions of the L-serine pathway, structure and enzymatic properties of the enzymes involved and genetic defects associated with this pathway.

Originele taal-2English
Pagina's (van-tot)256-262
Aantal pagina's7
TijdschriftMolecular Genetics and Metabolism
Volume99
Nummer van het tijdschrift3
DOI's
StatusPublished - 2010
Extern gepubliceerdJa

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