Language outcomes in children who underwent surgery for the removal of a posterior fossa tumor: A systematic review

Cheyenne Svaldi*, Effy Ntemou, Roel Jonkers, Saskia Kohnen, Vânia de Aguiar

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Background
Children who underwent posterior fossa tumor removal may have spoken or written language impairments. The present systematic review synthesized the literature regarding the language outcomes in this population. Benefits of this work were the identification of shortcomings in the literature and a starting point toward formulating guidelines for postoperative language assessment.
Methods
A systematic literature search was conducted, identifying studies with patients who had posterior fossa surgery before 18 years of age. Included studies were narratively synthesized to understand language outcomes by language function (e.g., phonology, morphosyntax) at a group and individual level. Furthermore, the influence of several mediators (e.g., postoperative cerebellar mutism syndrome (pCMS), tumor type) was investigated. A critical evaluation of the language assessment tools was conducted.
Results
The narrative synthesis of 66 studies showed that a broad spectrum of language impairments has been described, characterized by a large interindividual heterogeneity. Patients younger at diagnosis, receiving treatment for a high-grade tumor and/or radiotherapy and diagnosed with pCMS seemed more prone to impairment. Several gaps in language assessment remain, such as a baseline preoperative assessment and the assessment of pragmatics and morphosyntax. Further, there were important methodological differences in existing studies which complicated our ability to accurately guide clinical practice.
Conclusion
Children who had posterior fossa surgery seem to be at risk for postoperative language impairment. These results stress the need for language follow-up in posterior fossa tumor survivors.
Originele taal-2English
Pagina's (van-tot)129-141
Aantal pagina's13
TijdschriftEuropean Journal of Paediatric Neurology
Volume48
Vroegere onlinedatum23-dec.-2023
DOI's
StatusPublished - jan.-2024

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