Late (> 5 years) regional lymph node metastasis of oral squamous cell carcinoma (SCC), proven by p53 mutation analysis

J. Alain Kummer*, Robert J. J. Van Es, J.W.M. Hoekstra

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)


Background: A late (>5 years) neck nodal metastasis of oral cancer, poses a problem to the clinician: is it a late metastasis or a metastasis of a (unknown) second primary tumour? Methods: A 50-year-old male was seen with a contralateral lymph node metastasis, 51/2 years after treatment of a pT2N1M0 carcinoma in the floor of the mouth. Both the late metastasis and the original tumour specimen were analysed for p53 mutations. Results: Both specimens showed an identical p53 mutation, thereby confirming the lymph node to be a late metastasis. Conclusions: A lymph node metastasis can occur more than 5 years after treatment of an oral squamous cell carcinoma. p53 mutation analysis is of help to discriminate it from a second primary tumour. (C) 2008 European Association for Cranio-Maxillofacial Surgery.

Originele taal-2English
Pagina's (van-tot)415-418
Aantal pagina's4
TijdschriftJournal of Cranio-Maxillofacial Surgery
Nummer van het tijdschrift7
StatusPublished - okt-2008

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