Late Mortality in Childhood Cancer Survivors according to Pediatric Cancer Diagnosis and Treatment Era in the Dutch LATER Cohort

LATER Study Group, Ellen Kilsdonk, Eline van Dulmen-den Broeder, Flora E. van Leeuwen, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Helena J. van der Pal, Dorine Bresters, A. B. Versluys, Rob Pieters, Michael Hauptmann, Monique W.M. Jaspers, Sebastian J.C. Neggers, Martine F. Raphael, Wim J.E. Tissing, Leontine C.M. Kremer*, Cécile M. Ronckers

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

6 Citaten (Scopus)
38 Downloads (Pure)


This multi-center cohort-study examined late mortality among 6,165 Dutch five-year childhood cancer survivors diagnosed 1963-2001. Clinical details and cause of death were based on medical records. Mortality was 12-fold that of the general population, with 51.3 additional deaths per 10,000 person-years (21.9 yrs median follow-up). Cumulative mortality 15 yrs post-diagnosis was 6.9%, predominantly from late recurrences; thereafter the absolute contribution of other health outcomes increased. Cumulative all-cause and recurrence-related mortality were highest for Central Nervous System and bone tumor survivors. All-cause, but not subsequent tumor and circulatory disease-related cumulative mortality, was highest for patients diagnosed 1963-1979 vs. later (p-trend <0.001).

Originele taal-2English
Pagina's (van-tot)413-424
Aantal pagina's12
TijdschriftCancer investigation
Nummer van het tijdschrift5
StatusPublished - 1-mei-2022

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