Life in the slow lane: a multi-omics approach to molecular adaptions in hibernating Syrian hamster liver

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    Hibernation is a physiological and behavioral adaptation that is characterized by two phases: torpor and arousal. During torpor, the body temperature and metabolic rate of the animal decreases dramatically. Contrastingly, arousal periods are identified by a rapid recovery of metabolism and normal physiology. Investigating these adaptations can aid in the development of new drugs in diseases and conditions associated with suppressed metabolism followed by metabolic activation, such as during transplantation, heart failure, or trauma. We investigated the underlying physiological changes in the hibernating Syrian hamster to provide a better understanding of the regulation of transcription, the cell cycle, and mitochondrial suppression during hamster hibernation. We found that these mechanisms may be regulated by epigenetic factors, such as histone acetylation. These insights can be used to develop future methods for limiting or preventing ischemia-reperfusion damage in various medical conditions.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    Begeleider(s)/adviseur
    • Henning, Rob, Supervisor
    • Rots, Marianne, Supervisor
    Datum van toekenning13-dec.-2023
    Plaats van publicatie[Groningen]
    Uitgever
    Gedrukte ISBN's978-94-6483-579-3
    DOI's
    StatusPublished - 2023

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