TY - JOUR
T1 - Lifelines COVID-19 cohort
T2 - investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
AU - Mc Intyre, Katherine
AU - Lanting, Pauline
AU - Deelen, Patrick
AU - Wiersma, Henry H
AU - Vonk, Judith M
AU - Ori, Anil P S
AU - Jankipersadsing, Soesma A
AU - Warmerdam, Robert
AU - van Blokland, Irene
AU - Boulogne, Floranne
AU - Dijkema, Marjolein X L
AU - Herkert, Johanna C
AU - Claringbould, Annique
AU - Bakker, Olivier
AU - Lopera Maya, Esteban A
AU - Bültmann, Ute
AU - Zhernakova, Alexandra
AU - Reijneveld, Sijmen A
AU - Zijlstra, Elianne
AU - Swertz, Morris A
AU - Brouwer, Sandra
AU - van Ooijen, Raun
AU - Angelini, Viola
AU - Dekker, Louise H
AU - Sijtsma, Anna
AU - Scherjon, Sicco A
AU - Wijmenga, Cisca
AU - Dekens, Jackie A M
AU - Mierau, Jochen
AU - Boezen, H Marike
AU - Franke, Lude
N1 - Funding Information:
Funding The Lifelines COVID-19 cohort is self-funded with in cash and in kind contributions from the initiators. The LLNEXT cohort is funded with a contribution of the UMCG Fund hereditary metabolic disorders (RVB16.0120). LF is supported by a Netherlands Organisation for Scientific Research (NWO) Corona Fast-Track grant (440.20.001), an Oncode Senior Investigator grant, a grant from the European Research Counsel (ERC Starting Grant agreement number 637640 ImmRisk) and an NWO VIDI grant (917.14.374). AZ is supported by the ERC Starting Grant 715772, NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27 and the NWO Gravitation grant ExposomeNL 024.004.017. JM and LHD are supported by an NWO Fast-track grant (440.20.002). MAS is supported by the EU Horizon2020 EUCAN-connect programme (824989).
Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
PY - 2021/3
Y1 - 2021/3
N2 - PURPOSE: The Lifelines COVID-19 cohort was set up to assess the psychological and societal impacts of the COVID-19 pandemic and investigate potential risk factors for COVID-19 within the Lifelines prospective population cohort.PARTICIPANTS: Participants were recruited from the 140 000 eligible participants of Lifelines and the Lifelines NEXT birth cohort, who are all residents of the three northern provinces of the Netherlands. Participants filled out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March 2020, and the cohort consists of everyone who filled in at least one questionnaire in the first 8 weeks of the project. FINDINGS TO DATE: >71 000 unique participants responded to the questionnaires at least once during the first 8 weeks, with >22 000 participants responding to seven questionnaires. Compiled questionnaire results are continuously updated and shared with the public through the Corona Barometer website. Early results included a clear signal that younger people living alone were experiencing greater levels of loneliness due to lockdown, and subsequent results showed the easing of anxiety as lockdown was eased in June 2020.FUTURE PLANS: Questionnaires were sent on a (bi)weekly basis starting in March 2020 and on a monthly basis starting July 2020, with plans for new questionnaire rounds to continue through 2020 and early 2021. Questionnaire frequency can be increased again for subsequent waves of infections. Cohort data will be used to address how the COVID-19 pandemic developed in the northern provinces of the Netherlands, which environmental and genetic risk factors predict disease susceptibility and severity and the psychological and societal impacts of the crisis. Cohort data are linked to the extensive health, lifestyle and sociodemographic data held for these participants by Lifelines, a 30-year project that started in 2006, and to data about participants held in national databases.
AB - PURPOSE: The Lifelines COVID-19 cohort was set up to assess the psychological and societal impacts of the COVID-19 pandemic and investigate potential risk factors for COVID-19 within the Lifelines prospective population cohort.PARTICIPANTS: Participants were recruited from the 140 000 eligible participants of Lifelines and the Lifelines NEXT birth cohort, who are all residents of the three northern provinces of the Netherlands. Participants filled out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March 2020, and the cohort consists of everyone who filled in at least one questionnaire in the first 8 weeks of the project. FINDINGS TO DATE: >71 000 unique participants responded to the questionnaires at least once during the first 8 weeks, with >22 000 participants responding to seven questionnaires. Compiled questionnaire results are continuously updated and shared with the public through the Corona Barometer website. Early results included a clear signal that younger people living alone were experiencing greater levels of loneliness due to lockdown, and subsequent results showed the easing of anxiety as lockdown was eased in June 2020.FUTURE PLANS: Questionnaires were sent on a (bi)weekly basis starting in March 2020 and on a monthly basis starting July 2020, with plans for new questionnaire rounds to continue through 2020 and early 2021. Questionnaire frequency can be increased again for subsequent waves of infections. Cohort data will be used to address how the COVID-19 pandemic developed in the northern provinces of the Netherlands, which environmental and genetic risk factors predict disease susceptibility and severity and the psychological and societal impacts of the crisis. Cohort data are linked to the extensive health, lifestyle and sociodemographic data held for these participants by Lifelines, a 30-year project that started in 2006, and to data about participants held in national databases.
KW - COVID-19
KW - public health
KW - epidemiology
KW - genetics
KW - mental health
U2 - 10.1136/bmjopen-2020-044474
DO - 10.1136/bmjopen-2020-044474
M3 - Article
C2 - 33737436
SN - 2044-6055
VL - 11
JO - BMJ Open
JF - BMJ Open
IS - 3
M1 - e044474
ER -