Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells

Rais Ahmad Khan; Khalid Al-Farhan; A.  de Almeida; Ali Alsalme; Angela Casini; Mohamed Ghazzali; Jan Reedijk

doi:10.1016/j.jinorgbio.2014.06.019

Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells

Rais Ahmad Khan
, Khalid Al-Farhan
, A. de Almeida
, Ali Alsalme
, Angela Casini
, Mohamed Ghazzali
, Jan Reedijk

Onderzoeksoutput › Academic › peer review

23 Citaten (Scopus)

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Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6(-) anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375nm, when excited at 290nm.

Originele taal-2	English
Pagina's (van-tot)	1-5
Aantal pagina's	5
Tijdschrift	Journal of Inorganic Biochemistry
Volume	140
DOI's	https://doi.org/10.1016/j.jinorgbio.2014.06.019
Status	Published - nov.-2014

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10.1016/j.jinorgbio.2014.06.019

Light-stable bis(norharmane)silver(I) compounds Synthesis, characterizationFinal publisher's version, 475 KBLicentie: Taverne

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CCDC 1000804: Experimental Crystal Structure Determination
Ahmad Khan, R. (Contributor), Al-Farhan, K. (Contributor), Batista de Almeida, A. (Contributor), Alsalme, A. (Contributor), Casini, A. (Contributor), Ghazzali, M. (Contributor) & Reedijk, J. (Contributor), University of Groningen, 4-mei-2014
DOI: 10.5517/cc12lf03
Dataset
CCDC 1000805: Experimental Crystal Structure Determination
Ahmad Khan, R. (Contributor), Al-Farhan, K. (Contributor), Batista de Almeida, A. (Contributor), Alsalme, A. (Contributor), Casini, A. (Contributor), Ghazzali, M. (Contributor) & Reedijk, J. (Contributor), University of Groningen, 4-mei-2014
DOI: 10.5517/cc12lf14
Dataset
CCDC 1000806: Experimental Crystal Structure Determination
Ahmad Khan, R. (Contributor), Al-Farhan, K. (Contributor), Batista de Almeida, A. (Contributor), Alsalme, A. (Contributor), Casini, A. (Contributor), Ghazzali, M. (Contributor) & Reedijk, J. (Contributor), University of Groningen, 4-mei-2014
DOI: 10.5517/cc12lf25
Dataset

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@article{7f5a9b28564b45ff82b5e1317112cfb0,

title = "Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells",

abstract = "Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6(-) anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375nm, when excited at 290nm.",

keywords = "SILVER(I) COMPLEXES, 9H-Pyrido[3,4-b]indole, antiproliferative properties, single crystal X-ray diffraction, linear geometry, LUMINESCENCE, SILVER SULFADIAZINE, complexes, norharman, LIGANDS, CYANIDE",

author = "\{Ahmad Khan\}, Rais and Khalid Al-Farhan and \{de Almeida\}, A. and Ali Alsalme and Angela Casini and Mohamed Ghazzali and Jan Reedijk",

year = "2014",

month = nov,

doi = "10.1016/j.jinorgbio.2014.06.019",

language = "English",

volume = "140",

pages = "1--5",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "ELSEVIER SCIENCE INC",

}

TY - JOUR

T1 - Light-stable bis(norharmane)silver(I) compounds

T2 - Synthesis, characterization and antiproliferative effects in cancer cells

AU - Ahmad Khan, Rais

AU - Al-Farhan, Khalid

AU - de Almeida, A.

AU - Alsalme, Ali

AU - Casini, Angela

AU - Ghazzali, Mohamed

AU - Reedijk, Jan

PY - 2014/11

Y1 - 2014/11

N2 - Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6(-) anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375nm, when excited at 290nm.

AB - Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6(-) anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375nm, when excited at 290nm.

KW - SILVER(I) COMPLEXES

KW - 9H-Pyrido[3,4-b]indole

KW - antiproliferative properties

KW - single crystal X-ray diffraction

KW - linear geometry

KW - LUMINESCENCE

KW - SILVER SULFADIAZINE

KW - complexes

KW - norharman

KW - LIGANDS

KW - CYANIDE

U2 - 10.1016/j.jinorgbio.2014.06.019

DO - 10.1016/j.jinorgbio.2014.06.019

M3 - Article

C2 - 25042730

SN - 0162-0134

VL - 140

SP - 1

EP - 5

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Light-stable bis(norharmane)silver(I) compounds: Synthesis, characterization and antiproliferative effects in cancer cells

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CCDC 1000804: Experimental Crystal Structure Determination

CCDC 1000805: Experimental Crystal Structure Determination

CCDC 1000806: Experimental Crystal Structure Determination

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