TY - JOUR
T1 - Linking bronchopulmonary dysplasia to adult chronic lung diseases
T2 - role of WNT signaling
AU - Ota, Chiharu
AU - Baarsma, Hoeke A
AU - Wagner, Darcy E
AU - Hilgendorff, Anne
AU - Königshoff, Melanie
PY - 2016/12
Y1 - 2016/12
N2 - Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
AB - Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.
KW - Review
KW - Journal Article
U2 - 10.1186/s40348-016-0062-6
DO - 10.1186/s40348-016-0062-6
M3 - Review article
C2 - 27718180
SN - 2194-7791
VL - 3
JO - Molecular and cellular pediatrics
JF - Molecular and cellular pediatrics
IS - 1
M1 - 34
ER -