Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins

Valentina Corradi, Eduardo Mendez-Villuendas, Helgi I Ingólfsson, Ruo-Xu Gu, Iwona Siuda, Manuel N Melo, Anastassiia Moussatova, Lucien J DeGagné, Besian I Sejdiu, Gurpreet Singh, Tsjerk A Wassenaar, Karelia Delgado Magnero, Siewert J Marrink, D Peter Tieleman

OnderzoeksoutputAcademicpeer review

79 Citaten (Scopus)
455 Downloads (Pure)

Samenvatting

Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell membranes remains rather elusive, because of the challenge to study fluctuating nanoscale assemblies of lipids and proteins with the required spatiotemporal resolution. Here, we use molecular dynamics simulations to characterize the lipid environment of 10 different membrane proteins. To provide a realistic lipid environment, the proteins are embedded in a model plasma membrane, where more than 60 lipid species are represented, asymmetrically distributed between the leaflets. The simulations detail how each protein modulates its local lipid environment in a unique way, through enrichment or depletion of specific lipid components, resulting in thickness and curvature gradients. Our results provide a molecular glimpse of the complexity of lipid-protein interactions, with potentially far-reaching implications for our understanding of the overall organization of real cell membranes.

Originele taal-2English
Pagina's (van-tot)709-717
Aantal pagina's9
TijdschriftACS central science
Volume4
Nummer van het tijdschrift6
DOI's
StatusPublished - 27-jun-2018

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