lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection

OnderzoeksoutputAcademicpeer review

3 Citaten (Scopus)

Samenvatting

Genome-wide association study (GWAS) of a biomarker is complicated when the assay procedure of the biomarker is restricted by a Limit of Detection (LOD). Those observations falling outside the LOD cannot be simply discarded, but should be included into the analysis by applying an appropriate statistical method. However, the problem of LOD in GWAS analysis of such biomarkers is usually overlooked. 'lodGWAS' is a flexible, easy-to-use R package that provides a simple and elegant way for GWAS analysis of such biomarkers while simultaneously accommodating the problem of LOD by applying a parametric survival analysis method.

Originele taal-2English
Pagina's (van-tot)1552-1554
Aantal pagina's3
TijdschriftBioinformatics (Oxford, England)
Volume32
Nummer van het tijdschrift10
Vroegere onlinedatum22-jan-2016
DOI's
StatusPublished - 15-mei-2016

Citeer dit