lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection

Ahmad Vaez; Peter J van der Most; Bram P Prins; Harold Snieder; Edwin van den Heuvel; Behrooz Z Alizadeh; Ilja M Nolte

doi:10.1093/bioinformatics/btw021

lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection

Ahmad Vaez, Peter J van der Most, Bram P Prins, Harold Snieder, Edwin van den Heuvel, Behrooz Z Alizadeh, Ilja M Nolte

Onderzoeksoutput: Article › Academic › peer review

5 Citaten (Scopus)

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Genome-wide association study (GWAS) of a biomarker is complicated when the assay procedure of the biomarker is restricted by a Limit of Detection (LOD). Those observations falling outside the LOD cannot be simply discarded, but should be included into the analysis by applying an appropriate statistical method. However, the problem of LOD in GWAS analysis of such biomarkers is usually overlooked. 'lodGWAS' is a flexible, easy-to-use R package that provides a simple and elegant way for GWAS analysis of such biomarkers while simultaneously accommodating the problem of LOD by applying a parametric survival analysis method.

Originele taal-2	English
Pagina's (van-tot)	1552-1554
Aantal pagina's	3
Tijdschrift	Bioinformatics (Oxford, England)
Volume	32
Nummer van het tijdschrift	10
Vroegere onlinedatum	22-jan.-2016
DOI's	https://doi.org/10.1093/bioinformatics/btw021
Status	Published - 15-mei-2016

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lodGWAS: Genome-Wide Association Analysis of a Biomarker Accounting for Limit of Detection: Genome-wide association (GWAS) analyses of a biomarker that account for the limit of detection.
Vaez, A. (Ontwikkelaar), Nolte, I. M. (Ontwikkelaar) & van der Most, P. J. (Ontwikkelaar), 2015
Onderzoeksoutput › Academic

Lifelines Biobank
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. M. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbutel, B. H. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006
https://www.lifelines.nl/ en nog één link, https://catalogue.lifelines.nl/ (minder tonen)
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AU - Alizadeh, Behrooz Z

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lodGWAS: a software package for genome-wide association analysis of biomarkers with a limit of detection

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lodGWAS: Genome-Wide Association Analysis of a Biomarker Accounting for Limit of Detection: Genome-wide association (GWAS) analyses of a biomarker that account for the limit of detection.

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Lifelines Biobank

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