TY - JOUR
T1 - Long Axial Field of View PET/CT
T2 - Technical Aspects in Cardiovascular Diseases
AU - Martinez-Lucio, Tonantzin Samara
AU - Mendoza-Ibañez, Oscar Isaac
AU - Liu, Wanling
AU - Mostafapour, Samaneh
AU - Li, Zekai
AU - Providência, Laura
AU - Salvi de Souza, Giordana
AU - Mohr, Philipp
AU - Dobrolinska, Magdalena M
AU - van Leer, Bram
AU - Tingen, Hendrea S A
AU - van Sluis, Joyce
AU - Tsoumpas, Charalampos
AU - Glaudemans, Andor W J M
AU - Koopmans, Klaas Pieter
AU - Lammertsma, Adriaan A
AU - Slart, Riemer H J A
N1 - Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2025/1
Y1 - 2025/1
N2 - Positron emission tomography / computed tomography (PET/CT) plays a pivotal role in the assessment of cardiovascular diseases (CVD), particularly in the context of ischemic heart disease. Nevertheless, its application in other forms of CVD, such as infiltrative, infectious, or inflammatory conditions, remains limited. Recently, PET/CT systems with an extended axial field of view (LAFOV) have been developed, offering greater anatomical coverage and significantly enhanced PET sensitivity. These advancements enable head-to-pelvis imaging with a single bed position, and in systems with an axial field of view (FOV) of approximately 2 meters, even total body (TB) imaging is feasible in a single scan session. The application of LAFOV PET/CT in CVD presents a promising opportunity to improve systemic cardiovascular assessments and address the limitations inherent to conventional short axial field of view (SAFOV) devices. However, several technical challenges, including procedural considerations for LAFOV systems in CVD, complexities in data processing, arterial input function extraction, and artefact management, have not been fully explored. This review aims to discuss the technical aspects of LAFOV PET/CT in relation to CVD by highlighting key opportunities and challenges and examining the impact of these factors on the evaluation of most relevant CVD.
AB - Positron emission tomography / computed tomography (PET/CT) plays a pivotal role in the assessment of cardiovascular diseases (CVD), particularly in the context of ischemic heart disease. Nevertheless, its application in other forms of CVD, such as infiltrative, infectious, or inflammatory conditions, remains limited. Recently, PET/CT systems with an extended axial field of view (LAFOV) have been developed, offering greater anatomical coverage and significantly enhanced PET sensitivity. These advancements enable head-to-pelvis imaging with a single bed position, and in systems with an axial field of view (FOV) of approximately 2 meters, even total body (TB) imaging is feasible in a single scan session. The application of LAFOV PET/CT in CVD presents a promising opportunity to improve systemic cardiovascular assessments and address the limitations inherent to conventional short axial field of view (SAFOV) devices. However, several technical challenges, including procedural considerations for LAFOV systems in CVD, complexities in data processing, arterial input function extraction, and artefact management, have not been fully explored. This review aims to discuss the technical aspects of LAFOV PET/CT in relation to CVD by highlighting key opportunities and challenges and examining the impact of these factors on the evaluation of most relevant CVD.
U2 - 10.1053/j.semnuclmed.2024.10.009
DO - 10.1053/j.semnuclmed.2024.10.009
M3 - Review article
C2 - 39537432
SN - 0001-2998
VL - 55
SP - 52
EP - 66
JO - Seminars in Nuclear Medicine
JF - Seminars in Nuclear Medicine
IS - 1
ER -