Long-term adverse effects of cancer treatment: Susceptibility and intervention strategies

Nico-Derk Lodewijk Westerink

Long-term adverse effects of cancer treatment: Susceptibility and intervention strategies

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Het aantal lange termijn overlevenden na kankerbehandeling neemt toe. Kankerbehandelingen kunnen bestaan uit chirurgie, radiotherapie en/of systemische therapie en kunnen bijwerkingen veroorzaken. Bijwerkingen zoals hart- en vaatziekten of hormonale stoornissen die vaak op lange termijn optreden, kunnen de overleving negatief beïnvloeden en de gezondheid schaden. Het is daarom belangrijk om deze bijwerkingen zo vroeg mogelijk te signaleren en indien mogelijk te voorkomen of te behandelen. Voorspellende markers of risicoprofielen waarmee patiënten met een verhoogd risico op lange termijn bijwerkingen kunnen worden geïdentificeerd, kunnen hierbij van grote waarde zijn.
Toekomstig onderzoek zou zich moeten richten op de ontstaanswijze hiervan, zodat passende maatregelen in een vroeg stadium kunnen worden getroffen. Leefstijl speelt een belangrijke rol in de ontstaanswijze van bepaalde kankersoorten en bij de kans op het ontstaan van lange termijn bijwerkingen na kankerbehandelingen. Verandering van leefstijl heeft mogelijk een positief effect hierop en gezonde leefstijl moet in de volle breedte van het zorgstelsel worden gepropageerd. Daarnaast moet toekomstig onderzoek bij kankerpatiënten op dit terrein zich focussen op therapietrouw, de invloed van intensiteit van fysieke training, dieetmaatregelen en optimale organisatie van leefstijlinterventies. Hierbij moet de patiënt met een eenvoudig nazorgplan centraal staan en zelf de regie hebben over het proces. Tenslotte moeten huisartsen meer betrokken zijn bij zorg voor kankeroverlevenden, de zorg ten aanzien van lange termijn bijwerkingen en leefstijladvies na kankerbehandeling. Een eerste stap zou bijvoorbeeld de ontwikkeling zijn van een huisartsenrichtlijn over zorg na kankerbehandeling.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Gietema, Jourik, Supervisor Vrieling, Aline, Co-supervisor Walenkamp-Hageman, Annemiek, Co-supervisor
Datum van toekenning	13-jun.-2018
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Status	Published - 2018

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Title and contentsFinal publisher's version, 702 KB
Chapter 1Final publisher's version, 583 KB
Chapter 2Final publisher's version, 826 KB
Chapter 3Final publisher's version, 1,33 MB
Chapter 4Final publisher's version, 1,35 MB
Chapter 5Final publisher's version, 2 MB
Chapter 6Final publisher's version, 1,76 MB
Chapter 7Final publisher's version, 717 KB
Chapter 8Final publisher's version, 619 KB
Chapter 9Final publisher's version, 561 KB
Supplemental filesFinal publisher's version, 667 KB
Dankwoord (Acknowledgements)Final publisher's version, 534 KB
Complete thesisFinal publisher's version, 6,45 MB
PropositionsFinal publisher's version, 543 KB

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@phdthesis{cd014d05feaa484daca340f00923a1d2,

title = "Long-term adverse effects of cancer treatment: Susceptibility and intervention strategies",

abstract = "Numbers of long-term cancer survivors are increasing. Cancer treatment like surgery, radiotherapy and/or systemic therapy can cause adverse effects. Adverse effects, like cardiovascular disease or hormonal disturbances can develop years after treatment and impair survival or health. It is important to detect these adverse effects at an early stage and to prevent or treat them if possible. Early markers or susceptibility profiles to identify patients at risk in order to prevent long-term adverse effects are of great value. Future studies should focus on the pathogenesis of adverse effects and how to intervene at an early stage. Lifestyle plays an important role in the pathogenesis of certain cancer types and also in the risk of developing long-term adverse effects after cancer treatment. Lifestyle change probably decreases this risk and therefore, lifestyle advice should be carried out throughout the healthcare system. Future lifestyle research in cancer patients should focus on adherence, intensity of physical exercise, dietary measures and optimal organization, with the use of a simple survivorship care plan which puts patients in control. General practioners should be involved in cancer survivorship care, management of long-term adverse effects of cancer treatment and lifestyle counseling after cancer treatment. Practical guidelines could be of assistance and should be drafted in the coming years.",

author = "Westerink, {Nico-Derk Lodewijk}",

year = "2018",

language = "English",

publisher = "Rijksuniversiteit Groningen",

school = "University of Groningen",

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TY - BOOK

T1 - Long-term adverse effects of cancer treatment

T2 - Susceptibility and intervention strategies

AU - Westerink, Nico-Derk Lodewijk

PY - 2018

Y1 - 2018

N2 - Numbers of long-term cancer survivors are increasing. Cancer treatment like surgery, radiotherapy and/or systemic therapy can cause adverse effects. Adverse effects, like cardiovascular disease or hormonal disturbances can develop years after treatment and impair survival or health. It is important to detect these adverse effects at an early stage and to prevent or treat them if possible. Early markers or susceptibility profiles to identify patients at risk in order to prevent long-term adverse effects are of great value. Future studies should focus on the pathogenesis of adverse effects and how to intervene at an early stage. Lifestyle plays an important role in the pathogenesis of certain cancer types and also in the risk of developing long-term adverse effects after cancer treatment. Lifestyle change probably decreases this risk and therefore, lifestyle advice should be carried out throughout the healthcare system. Future lifestyle research in cancer patients should focus on adherence, intensity of physical exercise, dietary measures and optimal organization, with the use of a simple survivorship care plan which puts patients in control. General practioners should be involved in cancer survivorship care, management of long-term adverse effects of cancer treatment and lifestyle counseling after cancer treatment. Practical guidelines could be of assistance and should be drafted in the coming years.

AB - Numbers of long-term cancer survivors are increasing. Cancer treatment like surgery, radiotherapy and/or systemic therapy can cause adverse effects. Adverse effects, like cardiovascular disease or hormonal disturbances can develop years after treatment and impair survival or health. It is important to detect these adverse effects at an early stage and to prevent or treat them if possible. Early markers or susceptibility profiles to identify patients at risk in order to prevent long-term adverse effects are of great value. Future studies should focus on the pathogenesis of adverse effects and how to intervene at an early stage. Lifestyle plays an important role in the pathogenesis of certain cancer types and also in the risk of developing long-term adverse effects after cancer treatment. Lifestyle change probably decreases this risk and therefore, lifestyle advice should be carried out throughout the healthcare system. Future lifestyle research in cancer patients should focus on adherence, intensity of physical exercise, dietary measures and optimal organization, with the use of a simple survivorship care plan which puts patients in control. General practioners should be involved in cancer survivorship care, management of long-term adverse effects of cancer treatment and lifestyle counseling after cancer treatment. Practical guidelines could be of assistance and should be drafted in the coming years.

M3 - Thesis fully internal (DIV)

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

Long-term adverse effects of cancer treatment: Susceptibility and intervention strategies

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