Long-term cerebral imaging after pre-eclampsia

A. M. Aukes, J. C. De Groot, M. J. Wiegman, J. G. Aarnoudse, G. S. Sanwikarja, G. G. Zeeman*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    68 Citaten (Scopus)


    Please cite this paper as: Aukes A, De Groot J, Wiegman M, Aarnoudse J, Sanwikarja G, Zeeman G. Long-term cerebral imaging after pre-eclampsia. BJOG 2012;119:11171122. Objective Formerly eclamptic women demonstrate cerebral white matter lesions (WMLs) several years following the index pregnancy. The pathophysiology is unclear and may be related to the predisposition for cerebrovascular/cardiovascular disease in such women and/or the occurrence of posterior reversible encephalopathy syndrome whilst pregnant. The aim of this study was to assess the presence and severity of WMLs and their relationship with the severity of the neurological symptoms during the index pregnancy and several current cardiovascular risk factors in formerly pre-eclamptic women. Design This was a retrospective cohort study. Setting The Neuroimaging Centre at the School for Behavioural and Cognitive Neurosciences, Groningen, the Netherlands. Population Seventy-three formerly pre-eclamptic women were matched for age (37 +/- 6 years) and elapsed time since index pregnancy (5.1 +/- 3.7 years) with parous control women. Methods Cerebral magnetic resonance imaging scans were performed on cases and controls. Scans were rated by a neuroradiologist blind to the patient category. Main outcome measures The presence and severity of cerebral WMLs. Results Formerly pre-eclamptic women had WMLs significantly more often (37%) and more severely (mean, 0.11; median, 0.00; range, 02.34 ml) than controls (21%, P = 0.04; mean, 0.015; median, 0.00; range, 00.13 ml; P = 0.02). Current hypertension and a history of early-onset pre-eclampsia (

    Originele taal-2English
    Pagina's (van-tot)1117-1122
    Aantal pagina's6
    TijdschriftBJOG-an International Journal Of Obstetrics And Gynaecology
    Nummer van het tijdschrift9
    StatusPublished - aug-2012

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