Low preoperative skeletal muscle density is predictive for negative postoperative outcomes in older women with ovarian cancer

Vera van der Zanden*, Neeltje J. van Soolingen, Alain R. Viddeleer, Johannes W. Trum, Frederic Amant, Marian J. E. Mourits, Johanneke E. A. Portielje, Frederiek van den Bos, Cornelis D. de Kroon, Marjolein J. Kagie, Stanley A. Oei, Astrid Baalbergen, Anne-Marie L. D. van Haaften-de Jong, Danny Houtsma, Barbara C. van Munster, Esteban T. D. Souwer

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

16 Citaten (Scopus)
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Objective. To determine the predictive value of lumbar skeletal muscle mass and density for postoperative outcomes in older women with advanced stage ovarian cancer.

Methods. A multicenter, retrospective cohort study was performed in women >= 70 years old receiving surgery for primary, advanced stage ovarian cancer. Skeletal muscle mass and density were assessed in axial CT slices on level L3. Low skeletal muscle mass was defined as skeletal muscle index < 38.50 cm(2)/m(2). Low skeletal muscle density was defined as one standard deviation below the mean (muscle attenuation < 22.55 Hounsfield Units). The primary outcome was any postoperative complication

Results. In analysis of 213 patients, preoperative low skeletal muscle density was associated with postopera-tive complications = 2).

Conclusion. Low skeletal muscle density, as a proxy of muscle quality, is associated with poor postoperative outcomes in older patients with advanced stage ovarian cancer. These findings can contribute to postoperative risk assessment and clinical decision making. (C) 2021 The Author(s). Published by Elsevier Inc.

Originele taal-2English
Pagina's (van-tot)360-367
Aantal pagina's8
TijdschriftGynecologic Oncology
Volume162
Nummer van het tijdschrift2
DOI's
StatusPublished - aug.-2021

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