Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease

Laura H. Eggermont; Brandon E. Gavett; Karin M. Volkers; Christiaan G. Blankevoort; Erik J. Scherder; Angela L. Jefferson; Eric Steinberg; Anil Nair; Robert C. Green; Robert A. Stern

doi:10.1016/j.apmr.2009.11.020

Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease

Laura H. Eggermont, Brandon E. Gavett, Karin M. Volkers, Christiaan G. Blankevoort, Erik J. Scherder, Angela L. Jefferson, Eric Steinberg, Anil Nair, Robert C. Green, Robert A. Stern^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

104 Citaten (Scopus)

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Eggermont LH, Gavett BE, Volkers KM, Blankevoort CG, Scherder EJ, Jefferson AL, Steinberg E, Nair A, Green RC, Stern RA. Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Arch Phys Med Rehabil 2010;91:584-8.

Objective: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).

Design: Descriptive study.

Setting: University Alzheimer's disease clinical and research program.

Participants: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.

Interventions: Not applicable.

Main Outcome Measures: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.

Results: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.

Conclusions: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

Originele taal-2	English
Pagina's (van-tot)	584-588
Aantal pagina's	5
Tijdschrift	Archives of Physical Medicine and Rehabilitation
Volume	91
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.apmr.2009.11.020
Status	Published - apr.-2010

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Eggermont, L. H., Gavett, B. E., Volkers, K. M., Blankevoort, C. G., Scherder, E. J., Jefferson, A. L., Steinberg, E., Nair, A., Green, R. C., & Stern, R. A. (2010). Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease. Archives of Physical Medicine and Rehabilitation, 91(4), 584-588. https://doi.org/10.1016/j.apmr.2009.11.020

@article{12813abf9463461fb6eae28613c57182,

title = "Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease",

abstract = "Eggermont LH, Gavett BE, Volkers KM, Blankevoort CG, Scherder EJ, Jefferson AL, Steinberg E, Nair A, Green RC, Stern RA. Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Arch Phys Med Rehabil 2010;91:584-8.Objective: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).Design: Descriptive study.Setting: University Alzheimer's disease clinical and research program.Participants: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.Interventions: Not applicable.Main Outcome Measures: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.Results: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.Conclusions: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.",

keywords = "Aging, Alzheimer disease, Cognition, Gait, Rehabilitation, FRAIL ELDERLY-PATIENTS, GAIT VELOCITY, DIVIDED ATTENTION, MOTOR DYSFUNCTION, STAND TEST, GO TEST, COMMUNITY, DEMENTIA, OLDER, PERFORMANCE",

author = "Eggermont, {Laura H.} and Gavett, {Brandon E.} and Volkers, {Karin M.} and Blankevoort, {Christiaan G.} and Scherder, {Erik J.} and Jefferson, {Angela L.} and Eric Steinberg and Anil Nair and Green, {Robert C.} and Stern, {Robert A.}",

year = "2010",

month = apr,

doi = "10.1016/j.apmr.2009.11.020",

language = "English",

volume = "91",

pages = "584--588",

journal = "Archives of Physical Medicine and Rehabilitation",

issn = "0003-9993",

publisher = "W B SAUNDERS CO-ELSEVIER INC",

number = "4",

}

TY - JOUR

T1 - Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease

AU - Eggermont, Laura H.

AU - Gavett, Brandon E.

AU - Volkers, Karin M.

AU - Blankevoort, Christiaan G.

AU - Scherder, Erik J.

AU - Jefferson, Angela L.

AU - Steinberg, Eric

AU - Nair, Anil

AU - Green, Robert C.

AU - Stern, Robert A.

PY - 2010/4

Y1 - 2010/4

N2 - Eggermont LH, Gavett BE, Volkers KM, Blankevoort CG, Scherder EJ, Jefferson AL, Steinberg E, Nair A, Green RC, Stern RA. Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Arch Phys Med Rehabil 2010;91:584-8.Objective: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).Design: Descriptive study.Setting: University Alzheimer's disease clinical and research program.Participants: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.Interventions: Not applicable.Main Outcome Measures: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.Results: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.Conclusions: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

AB - Eggermont LH, Gavett BE, Volkers KM, Blankevoort CG, Scherder EJ, Jefferson AL, Steinberg E, Nair A, Green RC, Stern RA. Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease. Arch Phys Med Rehabil 2010;91:584-8.Objective: To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).Design: Descriptive study.Setting: University Alzheimer's disease clinical and research program.Participants: Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.Interventions: Not applicable.Main Outcome Measures: Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.Results: Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.Conclusions: These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.

KW - Aging

KW - Alzheimer disease

KW - Cognition

KW - Gait

KW - Rehabilitation

KW - FRAIL ELDERLY-PATIENTS

KW - GAIT VELOCITY

KW - DIVIDED ATTENTION

KW - MOTOR DYSFUNCTION

KW - STAND TEST

KW - GO TEST

KW - COMMUNITY

KW - DEMENTIA

KW - OLDER

KW - PERFORMANCE

U2 - 10.1016/j.apmr.2009.11.020

DO - 10.1016/j.apmr.2009.11.020

M3 - Article

SN - 0003-9993

VL - 91

SP - 584

EP - 588

JO - Archives of Physical Medicine and Rehabilitation

JF - Archives of Physical Medicine and Rehabilitation

IS - 4

ER -

Lower-Extremity Function in Cognitively Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease

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