Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

E. O. G. van Vliet; L. Seinen; C. Roos; E. Schuit; H. C. J. Scheepers; K. W. M. Bloemenkamp; J. J. Duvekot; J. van Eyck; J. H. Kok; F. K. Lotgering; A. van Baar; A. G. van Wassenaer-Leemhuis; M. T. Franssen; M. M. Porath; J. A. M. van der Post; A. Franx; B. W. J. Mol; M. A. Oudijk

doi:10.1111/1471-0528.13586

Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

E. O. G. van Vliet, L. Seinen, C. Roos, E. Schuit, H. C. J. Scheepers, K. W. M. Bloemenkamp, J. J. Duvekot, J. van Eyck, J. H. Kok, F. K. Lotgering, A. van Baar, A. G. van Wassenaer-Leemhuis, M. T. Franssen, M. M. Porath, J. A. M. van der Post, A. Franx, B. W. J. Mol, M. A. Oudijk^*

^*Corresponding author voor dit werk

Reproductive Origins of Adult Health and Disease (ROAHD)

Onderzoeksoutput › Academic › peer review

13 Citaten (Scopus)

Samenvatting

Objective To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant.

Design, Setting and Population Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo.

Methods Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire.

Main outcome measures Infant development was measured in five domains. Developmental delay was defined as a score of

Results Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04).

Conclusions This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time.

Originele taal-2	English
Pagina's (van-tot)	1107-1114
Aantal pagina's	8
Tijdschrift	BJOG : An International Journal of Obstetrics and Gynaecology
Volume	123
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1111/1471-0528.13586
Status	Published - jun.-2016

Toegang tot document

10.1111/1471-0528.13586

Handle.net

Permanente koppeling

Document onder embargo

Maintenance tocolysis with nifedipine in threatened preterm labour 2-year
Final publisher's version, 206 KB
Kopie aanvragen

Citeer dit

van Vliet, E. O. G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C. J., Bloemenkamp, K. W. M., Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A. M., Franx, A., Mol, B. W. J., & Oudijk, M. A. (2016). Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial. BJOG : An International Journal of Obstetrics and Gynaecology, 123(7), 1107-1114. https://doi.org/10.1111/1471-0528.13586

@article{91ea09af71004fcca18be6b457491a0b,

title = "Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial",

abstract = "Objective To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant.Design, Setting and Population Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo.Methods Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire.Main outcome measures Infant development was measured in five domains. Developmental delay was defined as a score ofResults Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04).Conclusions This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time.",

keywords = "Maintenance tocolysis, nifedipine, outcome, preterm birth, RANDOMIZED CONTROLLED-TRIAL, PREMATURE-INFANTS, OUTCOMES, MANAGEMENT, RITODRINE, PLACEBO, INJURY, BLOOD, WOMEN, BIRTH",

author = "{van Vliet}, {E. O. G.} and L. Seinen and C. Roos and E. Schuit and Scheepers, {H. C. J.} and Bloemenkamp, {K. W. M.} and Duvekot, {J. J.} and {van Eyck}, J. and Kok, {J. H.} and Lotgering, {F. K.} and {van Baar}, A. and {van Wassenaer-Leemhuis}, {A. G.} and Franssen, {M. T.} and Porath, {M. M.} and {van der Post}, {J. A. M.} and A. Franx and Mol, {B. W. J.} and Oudijk, {M. A.}",

year = "2016",

month = jun,

doi = "10.1111/1471-0528.13586",

language = "English",

volume = "123",

pages = "1107--1114",

journal = "BJOG : An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "Wiley",

number = "7",

}

van Vliet, EOG, Seinen, L, Roos, C, Schuit, E, Scheepers, HCJ, Bloemenkamp, KWM, Duvekot, JJ, van Eyck, J, Kok, JH, Lotgering, FK, van Baar, A, van Wassenaer-Leemhuis, AG, Franssen, MT, Porath, MM, van der Post, JAM, Franx, A, Mol, BWJ & Oudijk, MA 2016, 'Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial', BJOG : An International Journal of Obstetrics and Gynaecology, vol. 123, nr. 7, blz. 1107-1114. https://doi.org/10.1111/1471-0528.13586

TY - JOUR

T1 - Maintenance tocolysis with nifedipine in threatened preterm labour

T2 - 2-year follow up of the offspring in the APOSTEL II trial

AU - van Vliet, E. O. G.

AU - Seinen, L.

AU - Roos, C.

AU - Schuit, E.

AU - Scheepers, H. C. J.

AU - Bloemenkamp, K. W. M.

AU - Duvekot, J. J.

AU - van Eyck, J.

AU - Kok, J. H.

AU - Lotgering, F. K.

AU - van Baar, A.

AU - van Wassenaer-Leemhuis, A. G.

AU - Franssen, M. T.

AU - Porath, M. M.

AU - van der Post, J. A. M.

AU - Franx, A.

AU - Mol, B. W. J.

AU - Oudijk, M. A.

PY - 2016/6

Y1 - 2016/6

N2 - Objective To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant.Design, Setting and Population Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo.Methods Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire.Main outcome measures Infant development was measured in five domains. Developmental delay was defined as a score ofResults Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04).Conclusions This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time.

AB - Objective To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant.Design, Setting and Population Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo.Methods Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire.Main outcome measures Infant development was measured in five domains. Developmental delay was defined as a score ofResults Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04).Conclusions This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years of age. As short-term adverse perinatal outcome was not reduced in the original APOSTEL II trial, we conclude that maintenance tocolysis does not appear to be beneficial at this time.

KW - Maintenance tocolysis

KW - nifedipine

KW - outcome

KW - preterm birth

KW - RANDOMIZED CONTROLLED-TRIAL

KW - PREMATURE-INFANTS

KW - OUTCOMES

KW - MANAGEMENT

KW - RITODRINE

KW - PLACEBO

KW - INJURY

KW - BLOOD

KW - WOMEN

KW - BIRTH

U2 - 10.1111/1471-0528.13586

DO - 10.1111/1471-0528.13586

M3 - Article

SN - 1470-0328

VL - 123

SP - 1107

EP - 1114

JO - BJOG : An International Journal of Obstetrics and Gynaecology

JF - BJOG : An International Journal of Obstetrics and Gynaecology

IS - 7

ER -

Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Samenvatting

Toegang tot document

Handle.net

Document onder embargo

Vingerafdruk

Citeer dit