Making More of Milk Sugar by Engineering Lactic Acid Bacteria

Willem M. de Vos; Pascal Hols; Richard van Kranenburg; Evert Luesink; Oscar P. Kuipers; John van der Oost; Michiel Kleerebezem; Jeroen Hugenholtz

doi:10.1016/S0958-6946(98)00049-1

Making More of Milk Sugar by Engineering Lactic Acid Bacteria

Willem M. de Vos, Pascal Hols, Richard van Kranenburg, Evert Luesink, Oscar P. Kuipers, John van der Oost, Michiel Kleerebezem, Jeroen Hugenholtz

Groningen Biomolecular Sciences and Biotechn.Inst.

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By exploiting their genetic and metabolic capacity, lactic acid bacteria can be used to generate a variety of products from milk sugar lactose other than the archetypical lactic acid. This review will outline the different genetic and metabolic engineering strategies that can be applied to lactic acid bacteria to realize this valorization of lactose. Attention will be given to the controlled production, by lactic acid bacteria, of enzymes that convert lactose. In addition, we will summarize the progress and potential of redirecting the metabolic flux from lactose to produce existing, modified, and novel metabolites. Examples to be discussed include the production of compounds that are relevant for the flavour, texture, and health aspects of foods.

Originele taal-2	English
Pagina's (van-tot)	227-233
Aantal pagina's	7
Tijdschrift	International Dairy Journal
Volume	8
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/S0958-6946(98)00049-1
Status	Published - 1998

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10.1016/S0958-6946(98)00049-1

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title = "Making More of Milk Sugar by Engineering Lactic Acid Bacteria",

abstract = "By exploiting their genetic and metabolic capacity, lactic acid bacteria can be used to generate a variety of products from milk sugar lactose other than the archetypical lactic acid. This review will outline the different genetic and metabolic engineering strategies that can be applied to lactic acid bacteria to realize this valorization of lactose. Attention will be given to the controlled production, by lactic acid bacteria, of enzymes that convert lactose. In addition, we will summarize the progress and potential of redirecting the metabolic flux from lactose to produce existing, modified, and novel metabolites. Examples to be discussed include the production of compounds that are relevant for the flavour, texture, and health aspects of foods.",

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AU - Vos, Willem M. de

AU - Hols, Pascal

AU - Kranenburg, Richard van

AU - Luesink, Evert

AU - Kuipers, Oscar P.

AU - Oost, John van der

AU - Kleerebezem, Michiel

AU - Hugenholtz, Jeroen

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AB - By exploiting their genetic and metabolic capacity, lactic acid bacteria can be used to generate a variety of products from milk sugar lactose other than the archetypical lactic acid. This review will outline the different genetic and metabolic engineering strategies that can be applied to lactic acid bacteria to realize this valorization of lactose. Attention will be given to the controlled production, by lactic acid bacteria, of enzymes that convert lactose. In addition, we will summarize the progress and potential of redirecting the metabolic flux from lactose to produce existing, modified, and novel metabolites. Examples to be discussed include the production of compounds that are relevant for the flavour, texture, and health aspects of foods.

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DO - 10.1016/S0958-6946(98)00049-1

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