Malnutrition in childhood cancer patients: A review on its prevalence and possible causes

Aeltsje Brinksma*, Gea Huizinga, Esther Sulkers, Willem Kamps, Petrie Roodbol, Wim Tissing

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

91 Citaten (Scopus)


Purpose: To perform a systematic literature review for critical evaluation of prevalence and factors contributing to malnutrition in childhood cancer.

Methods: A systematic search resulting in 46 suitable articles.

Results: Due to lack of uniform criteria and adequate studies, the prevalence rates of malnutrition can only be estimated. Based on strengths and weaknesses of included references, prevalence rates are estimated to be 0-10% for leukemia, 20-50% for neuroblastoma, and 0-30% for other malignancies. Whether energy deficiency or inflammation contributed to malnutrition could not be confirmed because the occurrence of energy deficit (low energy intake, increased metabolic rate) or inflammation (related to cachexia) was not convincing. Also, a relationship between these factors and malnutrition was not studied.

Conclusion: Longitudinal studies are needed to determine which children are at risk of malnutrition, and to investigate the impact of energy deficiency and inflammation on the nutritional status and body composition of childhood cancer patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)249-275
Aantal pagina's27
TijdschriftCritical Reviews in Oncology/Hematology
Nummer van het tijdschrift2
StatusPublished - aug-2012

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