Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Juana M Pérez, Roxana Postolache, Marta Castiñeira Reis, Esther G. Sinnema, Denisa Vargová, Folkert de Vries, Edwin Otten, Luo Ge*, Syuzanna R Harutyunyan*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

Originele taal-2English
Pagina's (van-tot)20071–20076
Aantal pagina's6
TijdschriftJournal of the American Chemical Society
Nummer van het tijdschrift48
Vroegere onlinedatum19-nov.-2021
StatusPublished - 8-dec.-2021

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