Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Juana M Pérez; Roxana Postolache; Marta Castiñeira Reis; Esther G. Sinnema; Denisa Vargová; Folkert de Vries; Edwin Otten; Luo Ge; Syuzanna R Harutyunyan

doi:10.1021/jacs.1c10756

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Juana M Pérez, Roxana Postolache, Marta Castiñeira Reis, Esther G. Sinnema, Denisa Vargová, Folkert de Vries, Edwin Otten, Luo Ge^*, Syuzanna R Harutyunyan^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

46 Citaten (Scopus)

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Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

Originele taal-2	English
Pagina's (van-tot)	20071–20076
Aantal pagina's	6
Tijdschrift	Journal of the American Chemical Society
Volume	143
Nummer van het tijdschrift	48
Vroegere onlinedatum	19-nov.-2021
DOI's	https://doi.org/10.1021/jacs.1c10756
Status	Published - 8-dec.-2021

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10.1021/jacs.1c10756Licentie: CC BY-NC-ND

Manganese(I)-Catalyzed H−P Bond Activation via Metal−Ligand CooperationFinal publisher's version, 1,71 MBLicentie: CC BY-NC-ND

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CCDC 2085290: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. R. (Contributor), The Cambridge Structural Database, 22-mei-2021
DOI: 10.5517/ccdc.csd.cc27zxfl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc27zxfl&sid=DataCite
Dataset
CCDC 2120248: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. R. (Contributor), The Cambridge Structural Database, 4-nov.-2021
DOI: 10.5517/ccdc.csd.cc29593x, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc29593x&sid=DataCite
Dataset
CCDC 2085460: Experimental Crystal Structure Determination
Pérez Galera, J. (Contributor), Postolache, R. (Contributor), Castiñeira Reis, M. (Contributor), Sinnema, E. (Contributor), Vargová, D. (Contributor), de Vries, F. (Contributor), Otten, E. (Contributor), Ge, L. (Contributor) & Harutyunyan, S. R. (Contributor), The Cambridge Structural Database, 23-mei-2021
DOI: 10.5517/ccdc.csd.cc2802x9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc2802x9&sid=DataCite
Dataset

Citeer dit

@article{f69aebef09024c2f860adab29d487a05,

title = "Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation",

abstract = "Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.",

author = "P{\'e}rez, {Juana M} and Roxana Postolache and {Casti{\~n}eira Reis}, Marta and Sinnema, {Esther G.} and Denisa Vargov{\'a} and {de Vries}, Folkert and Edwin Otten and Luo Ge and Harutyunyan, {Syuzanna R}",

year = "2021",

month = dec,

day = "8",

doi = "10.1021/jacs.1c10756",

language = "English",

volume = "143",

pages = "20071–20076",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "AMER CHEMICAL SOC",

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TY - JOUR

T1 - Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

AU - Pérez, Juana M

AU - Postolache, Roxana

AU - Castiñeira Reis, Marta

AU - Sinnema, Esther G.

AU - Vargová, Denisa

AU - de Vries, Folkert

AU - Otten, Edwin

AU - Ge, Luo

AU - Harutyunyan, Syuzanna R

PY - 2021/12/8

Y1 - 2021/12/8

N2 - Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

AB - Here we report that chiral Mn(I) complexes are capable of H-P bond activation. This activation mode enables a general method for the hydrophosphination of internal and terminal α,β-unsaturated nitriles. Metal-ligand cooperation, a strategy previously not considered for catalytic H-P bond activation, is at the base of the mechanistic action of the Mn(I)-based catalyst. Our computational studies support a stepwise mechanism for the hydrophosphination and provide insight into the origin of the enantioselectivity.

U2 - 10.1021/jacs.1c10756

DO - 10.1021/jacs.1c10756

M3 - Article

C2 - 34797634

SN - 0002-7863

VL - 143

SP - 20071

EP - 20076

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 48

ER -

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

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Datasets

CCDC 2085290: Experimental Crystal Structure Determination

CCDC 2120248: Experimental Crystal Structure Determination

CCDC 2085460: Experimental Crystal Structure Determination

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