Maternal and pup genotype contribution to growth in wild-type and tau mutant Syrian hamsters

Malgorzata Oklejewicz, Ido Pen, Geesje C.R. Durieux, Serge Daan

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)


The single gene mutation tau in the Syrian hamster-apart from its effect on the circadian organization of locomotor activity-has a pronounced influence on body weight. In this study we investigate the impact of maternal and pup genotypes at the tau-locus on the growth rate of pups. Homozygous tau mutant hamsters (circadian period of 20 hours) had lower growth rates and adult body weights than wild-type hamsters, whereas heterozygous tau mutants (circadian period of 22 hours) were intermediate. In addition, heterozygous pups from heterozygous dams grew heavier than those from wild-type and homozygous dams. The effect of maternal genotype was further evaluated in a cross-foster design, where wild-type and homozygous mutant pups were fostered at birth to either wild-type or homozygous mutant dams. At all ages, the maternal tau genotype had a negative effect on body weight, whereas the pup tau genotype had a positive effect during the preweaning period and a negative effect afterward.

Originele taal-2English
Pagina's (van-tot)383-391
Aantal pagina's9
TijdschriftBehavior Genetics
Nummer van het tijdschrift4
StatusPublished - jul.-2001

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