TY - JOUR
T1 - Maternal antihypertensive drugs may influence cerebral oxygen extraction in preterm infants during the first days after birth
AU - Verhagen, Elise A.
AU - Kooi, Elisabeth M. W.
AU - van den Berg, Paul P.
AU - Bos, Arend F.
PY - 2013/6
Y1 - 2013/6
N2 - Objective: To determine whether maternal antihypertensive drugs influenced cerebral oxygenation in preterm infants during the first days after birth.Methods: We included 49 preterm infants (median gestational age 30.3 weeks, (range 26.0-31.9), birth weight 1250 g (560-2250)). Regional cerebral oxygen saturation (r(c)SO(2)) was measured by near-infrared spectroscopy on postnatal days 1, 2, 3, 4 and 5. Fractional tissue oxygen extraction (FTOE) was calculated using r(c)SO(2) and arterial oxygen saturation (SpO(2)) values:(SpO(2) - rcSO(2))/SpO(2).Results: Nine mothers were treated with labetalol and/or MgSO4 during pregnancy, three mothers with labetalol, MgSO4 and nifedipine, and 19 mothers with nifedipine only. Eighteen infants served as controls. Multivariate linear regression analysis showed that exposure to labetalol and/or MgSO4 during pregnancy decreased FTOE on day 1 after birth, while nifedipine did not.Conclusions: Treating pregnant women with labetalol and/or MgSO4 may influence cerebral oxygen extraction in their offspring shortly after birth.
AB - Objective: To determine whether maternal antihypertensive drugs influenced cerebral oxygenation in preterm infants during the first days after birth.Methods: We included 49 preterm infants (median gestational age 30.3 weeks, (range 26.0-31.9), birth weight 1250 g (560-2250)). Regional cerebral oxygen saturation (r(c)SO(2)) was measured by near-infrared spectroscopy on postnatal days 1, 2, 3, 4 and 5. Fractional tissue oxygen extraction (FTOE) was calculated using r(c)SO(2) and arterial oxygen saturation (SpO(2)) values:(SpO(2) - rcSO(2))/SpO(2).Results: Nine mothers were treated with labetalol and/or MgSO4 during pregnancy, three mothers with labetalol, MgSO4 and nifedipine, and 19 mothers with nifedipine only. Eighteen infants served as controls. Multivariate linear regression analysis showed that exposure to labetalol and/or MgSO4 during pregnancy decreased FTOE on day 1 after birth, while nifedipine did not.Conclusions: Treating pregnant women with labetalol and/or MgSO4 may influence cerebral oxygen extraction in their offspring shortly after birth.
KW - Cerebral oxygenation
KW - fractional tissue oxygen extraction
KW - maternal antihypertensive drugs
KW - near-infrared spectroscopy
KW - preterm infants
KW - PREGNANCY-INDUCED HYPERTENSION
KW - RANDOMIZED-CONTROLLED-TRIAL
KW - NEAR-INFRARED SPECTROSCOPY
KW - VENA-CAVA FLOW
KW - MAGNESIUM-SULFATE
KW - BLOOD-FLOW
KW - FETAL HEMODYNAMICS
KW - TISSUE OXYGENATION
KW - WAVE-FORMS
KW - LABETALOL
U2 - 10.3109/14767058.2013.766695
DO - 10.3109/14767058.2013.766695
M3 - Article
VL - 26
SP - 871
EP - 876
JO - Journal of Maternal-Fetal & Neonatal Medicine
JF - Journal of Maternal-Fetal & Neonatal Medicine
IS - 9
ER -