Maternal control of haplodiploid sex determination in the wasp Nasonia

Eveline C. Verhulst, Leo W. Beukeboom, Louis van de Zande*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

143 Citaten (Scopus)
792 Downloads (Pure)


All insects in the order Hymenoptera have haplodiploid sex determination, in which males emerge from haploid unfertilized eggs and females are diploid. Sex determination in the honeybee Apis mellifera is controlled by the complementary sex determination (csd) locus, but the mechanisms controlling sex determination in other Hymenoptera without csd are unknown. We identified the sex-determination system of the parasitic wasp Nasonia, which has no csd locus. Instead, maternal input of Nasonia vitripennis transformer (Nvtra) messenger RNA, in combination with specific zygotic Nvtra transcription, in which Nvtra autoregulates female-specific splicing, is essential for female development. Our data indicate that males develop as a result of maternal imprinting that prevents zygotic transcription of the maternally derived Nvtra allele in unfertilized eggs. Upon fertilization, zygotic Nvtra transcription is initiated, which autoregulates the female-specific transcript, leading to female development.

Originele taal-2English
Pagina's (van-tot)620-623
Aantal pagina's4
Nummer van het tijdschrift5978
StatusPublished - 30-apr.-2010

Citeer dit