Mbth-like proteins in eukaryotic nrps-catalyzed processes

Roelof Ary Lans Bovenberg (Uitvinder), Ulrike Maria Muller (Uitvinder), Arnold Jacob Mathieu Driessen (Uitvinder), Carsten Pohl (Uitvinder), Reto Daniel Zwahlen (Uitvinder)

Onderzoeksoutput

Samenvatting

The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.
Originele taal-2English
OctrooinummerWO2017178624
Prioriteitsdatum14/04/2016
StatusPublished - 19-okt.-2017

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