Mechanisms of cellular resistance to cisplatin

G. A. P. Hospers*, N. H. Mulder, E. G. E. de Vries

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

35 Citaten (Scopus)


Treatment of cancer patients often fails because of the resistance in the tumor to chemotherapeutic drugs. A better understanding of mechanisms which are active in resistant cells might lead to measures to circumvent the resistance. This review deals with the mechanisms of action of cisplatin (CDDP) and the various causes for CDDP resistance in the tumor cells. Also, possibilities to circumvent CDDP resistancein vitro andin vivo are presented.
Originele taal-2English
Pagina's (van-tot)145-151
Aantal pagina's7
TijdschriftMedical oncology and tumor pharmacotherapy
Nummer van het tijdschrift3
StatusPublished - 1988

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