TY - JOUR
T1 - Mechanisms underlying elevated SBP differ with adiposity in young adults
T2 - the Enigma study
AU - Middlemiss, Jessica E.
AU - Miles, Karen L.
AU - McDonnell, Barry J.
AU - Yasmin, null
AU - Maki-Petaja, Kaisa M.
AU - Cockcroft, John R.
AU - Wilkinson, Ian B.
AU - McEniery, Carmel M.
AU - Enigma Study Investigators
AU - Hartman, C.A.
AU - Hoekstra, Pieter J.
AU - van Tol, M.-J
PY - 2016/2
Y1 - 2016/2
N2 - Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P
AB - Objectives:The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high BP in normal-weight versus overweight individuals. The aim of the current study was to examine the influence of adiposity on the relationship between SBP and underlying haemodynamic mechanisms in young adults.Method:Data from 2502 patients were available from the Enigma study. Detailed demographic, biochemical, and haemodynamic data were obtained in all individuals. Data were analysed between lower and upper tertiles of BMI and SBP, separately for each sex.Results:In normal-weight individuals, cardiac output (CO) was elevated in those with higher SBP, independently of body size. Moreover, higher CO was associated with an increased stroke volume in men (P
KW - adiposity
KW - BMI
KW - cardiac output
KW - peripheral vascular resistance
KW - SBP
KW - ISOLATED SYSTOLIC HYPERTENSION
KW - AMBULATORY BLOOD-PRESSURE
KW - OBESITY-INDUCED HYPERTENSION
KW - GAS REBREATHING TECHNIQUE
KW - BODY-MASS INDEX
KW - CARDIAC-OUTPUT
KW - BORDERLINE HYPERTENSION
KW - NONINVASIVE MEASUREMENT
KW - INTRAVASCULAR VOLUME
KW - SCIENTIFIC STATEMENT
U2 - 10.1097/HJH.0000000000000798
DO - 10.1097/HJH.0000000000000798
M3 - Article
SN - 0263-6352
VL - 34
SP - 290
EP - 297
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 2
ER -