Mechanistic journeys into lipid metabolism

Federico Oldoni

Mechanistic journeys into lipid metabolism

Vertaalde titel van de bijdrage: Mechanische reizen naar lipidenmetabolisme

Federico Oldoni

Onderzoeksoutput: Thesis fully internal (DIV)

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Samenvatting

Het algemene doel van dit proefschrift betreft de functionele karakterisatie van nieuwe spelers (GPR146) dan wel het ontrafelen van nieuwe rollen van oude spelers (LRP1, ANGPTL3) die betrokken zijn bij dyslipidemie, een gestoorde glucosehuishouding (GALNT2) en/of atherosclerose (LPL, APOA5, LCAT). Er is in dit kader met name aandacht besteed aan moleculaire mechanismes die relevant zijn voor humane ziekebeelden. Hiertoe zijn verschillende benaderingen gebruikt waaronder het uitvoeren van onderzoek in prospectieve humane cohort studies, cellulaire en ook diermodellen.

Vertaalde titel van de bijdrage	Mechanische reizen naar lipidenmetabolisme
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Kuivenhoven, Jan Albert, Supervisor Sinke, Richard, Supervisor van de Sluis, Bart, Supervisor
Datum van toekenning	16-okt.-2017
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-94-034-0094-5
Elektronische ISBN's	978-94-034-0093-8
Status	Published - 2017

Toegang tot document

Title and contentsFinal publisher's version, 797 KB
Chapter 1Final publisher's version, 709 KB
Chapter 2Final publisher's version, 1,3 MB
Chapter 3Final publisher's version, 2,15 MB
Chapter 4Final publisher's version, 1,69 MB
Chapter 5Final publisher's version, 1,21 MB
Chapter 6Final publisher's version, 1,69 MB
Chapter 7Final publisher's version, 1,3 MB
Chapter 8Final publisher's version, 1,28 MB
Chapter 9Final publisher's version, 419 KB
AppendicesFinal publisher's version, 2,13 MB
Complete thesisFinal publisher's version, 13,3 MB
PropositionsFinal publisher's version, 265 KB

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title = "Mechanistic journeys into lipid metabolism",

abstract = "The general scope of this thesis embraces the functional characterization of novel players or the unravelling of new roles for old players involved in dyslipidemia, impaired glucose homeostasis and atherosclerosis. Major attention is given to key molecular pathways relevant to diseased phenotypes. This was addressed by means of a wide-range of approaches including human prospective cohort studies, cellular and animal models. Three main topics are described as follows: the first part is focused on the characterization of known (LRP1) and novel (GPR146) receptors in lipid metabolism (Chapters 3 and 4). The role of established factors directly influencing HDL maturation (LCAT) or indirectly affecting HDL remodelling through TG (ANGPTL3) and their effect on cardiovascular disease is covered in Chapters 5 and 6. Finally, factors affecting triglycerides (LPL, APOA5) and carbohydrate metabolism (GALNT2) are studied in the context of metabolic syndrome in Chapters 7 and 8.",

author = "Federico Oldoni",

year = "2017",

language = "English",

isbn = "978-94-034-0094-5",

publisher = "University of Groningen",

school = "University of Groningen",

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TY - THES

T1 - Mechanistic journeys into lipid metabolism

AU - Oldoni, Federico

PY - 2017

Y1 - 2017

N2 - The general scope of this thesis embraces the functional characterization of novel players or the unravelling of new roles for old players involved in dyslipidemia, impaired glucose homeostasis and atherosclerosis. Major attention is given to key molecular pathways relevant to diseased phenotypes. This was addressed by means of a wide-range of approaches including human prospective cohort studies, cellular and animal models. Three main topics are described as follows: the first part is focused on the characterization of known (LRP1) and novel (GPR146) receptors in lipid metabolism (Chapters 3 and 4). The role of established factors directly influencing HDL maturation (LCAT) or indirectly affecting HDL remodelling through TG (ANGPTL3) and their effect on cardiovascular disease is covered in Chapters 5 and 6. Finally, factors affecting triglycerides (LPL, APOA5) and carbohydrate metabolism (GALNT2) are studied in the context of metabolic syndrome in Chapters 7 and 8.

AB - The general scope of this thesis embraces the functional characterization of novel players or the unravelling of new roles for old players involved in dyslipidemia, impaired glucose homeostasis and atherosclerosis. Major attention is given to key molecular pathways relevant to diseased phenotypes. This was addressed by means of a wide-range of approaches including human prospective cohort studies, cellular and animal models. Three main topics are described as follows: the first part is focused on the characterization of known (LRP1) and novel (GPR146) receptors in lipid metabolism (Chapters 3 and 4). The role of established factors directly influencing HDL maturation (LCAT) or indirectly affecting HDL remodelling through TG (ANGPTL3) and their effect on cardiovascular disease is covered in Chapters 5 and 6. Finally, factors affecting triglycerides (LPL, APOA5) and carbohydrate metabolism (GALNT2) are studied in the context of metabolic syndrome in Chapters 7 and 8.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-0094-5

PB - University of Groningen

CY - [Groningen]

ER -