Mediators of the association between depression and role functioning

M. A. Buist-Bouwman, J. Ormel, R. de Graaf, P. de Jonge*, E. van Sonderen, J. Alonso, R. Bruffaerts, W. A. M. Vollebergh, ESEMed MHEDEA 2000 investigators

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

111 Citaten (Scopus)


While the adverse effect of Major Depressive Episode on role functioning is well established, the exact pathways remain unclear.

Data from The European Study of the Epidemiology of Mental Disorders, a cross-sectional survey including 21 425 adults from six European countries, were used to assess 12-month depression (Composite International Diagnostic Interview), activity limitations and role functioning in the past 30 days (Disability Assessment Schedule). An a priori model based on the World Health Organization's International Classification of Functioning, Disability and Health was designed and a structural equation model for categorical and ordinal data was used (MPlus) to estimate the extent to which six limitations mediated the association between depression and role functioning.

The unadjusted association between depression and role functioning was strong (0.43; SE = 0.04). In the best-fitting model, only concentration and attention problems and embarrassment mediated a significant amount of association (direct effect dropped to 0.17; SE = 0.10, which was no longer significant).

Targeting cognition and embarrassment in treatment could help reduce depression-associated role disfunctioning.

Originele taal-2English
Pagina's (van-tot)451-458
Aantal pagina's8
TijdschriftActa Psychiatrica Scandinavica
Nummer van het tijdschrift6
StatusPublished - dec.-2008

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