MEIS and PBX homeobox proteins in ovarian cancer

A. P. G. Crijns; P. de Graeff; D. Geerts; K. A. ten Hoor; H. Hollema; T. van der Sluis; R. M. W. Hofstra; G. H. de Bock; S. de Jong; A. G. J. van der Zee; E. G. E. de Vries

doi:10.1016/j.ejca.2007.08.025

MEIS and PBX homeobox proteins in ovarian cancer

A. P. G. Crijns
, P. de Graeff
, D. Geerts
, K. A. ten Hoor
, H. Hollema
, T. van der Sluis
, R. M. W. Hofstra
, G. H. de Bock
, S. de Jong
, A. G. J. van der Zee
, E. G. E. de Vries^*

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved

Originele taal-2	English
Pagina's (van-tot)	2495-2505
Aantal pagina's	11
Tijdschrift	European Journal of Cancer
Volume	43
Nummer van het tijdschrift	17
DOI's	https://doi.org/10.1016/j.ejca.2007.08.025
Status	Published - nov.-2007

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@article{725bb4f52462489593980c449d6cb73b,

title = "MEIS and PBX homeobox proteins in ovarian cancer",

abstract = "Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved",

keywords = "ovarian cancer, immunohistochemistry, tissue microarray, homeobox proteins, MEIS, PBX, GENE-EXPRESSION PROFILES, HOX GENES, DNA-BINDING, EPITHELIAL-CELLS, P53 EXPRESSION, NCBI GEO, APOPTOSIS, IDENTIFICATION, TRANSLOCATION, MILLIONS",

author = "Crijns, \{A. P. G.\} and \{de Graeff\}, P. and D. Geerts and \{ten Hoor\}, \{K. A.\} and H. Hollema and \{van der Sluis\}, T. and Hofstra, \{R. M. W.\} and \{de Bock\}, \{G. H.\} and \{de Jong\}, S. and \{van der Zee\}, \{A. G. J.\} and \{de Vries\}, \{E. G. E.\}",

year = "2007",

month = nov,

doi = "10.1016/j.ejca.2007.08.025",

language = "English",

volume = "43",

pages = "2495--2505",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "ELSEVIER SCI LTD",

number = "17",

}

TY - JOUR

T1 - MEIS and PBX homeobox proteins in ovarian cancer

AU - Crijns, A. P. G.

AU - de Graeff, P.

AU - Geerts, D.

AU - ten Hoor, K. A.

AU - Hollema, H.

AU - van der Sluis, T.

AU - Hofstra, R. M. W.

AU - de Bock, G. H.

AU - de Jong, S.

AU - van der Zee, A. G. J.

AU - de Vries, E. G. E.

PY - 2007/11

Y1 - 2007/11

N2 - Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved

AB - Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N = 232) of ovarian cancers and ovarian surface epithelium (N = 15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis. (c) 2007 Elsevier Ltd. All rights reserved

KW - ovarian cancer

KW - immunohistochemistry

KW - tissue microarray

KW - homeobox proteins

KW - MEIS

KW - PBX

KW - GENE-EXPRESSION PROFILES

KW - HOX GENES

KW - DNA-BINDING

KW - EPITHELIAL-CELLS

KW - P53 EXPRESSION

KW - NCBI GEO

KW - APOPTOSIS

KW - IDENTIFICATION

KW - TRANSLOCATION

KW - MILLIONS

U2 - 10.1016/j.ejca.2007.08.025

DO - 10.1016/j.ejca.2007.08.025

M3 - Article

SN - 0959-8049

VL - 43

SP - 2495

EP - 2505

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 17

ER -

MEIS and PBX homeobox proteins in ovarian cancer

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