Membrane supply and remodeling during autophagosome biogenesis

Rubén Gómez-Sánchez, Sharon A Tooze, Fulvio Reggiori*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

23 Citaten (Scopus)
41 Downloads (Pure)

Samenvatting

The de novo generation of double-membrane autophagosomes is the hallmark of autophagy. The initial membranous precursor cisterna, the phagophore, is very likely generated by the fusion of vesicles and acts as a membrane seed for the subsequent expansion into an autophagosome. This latter step requires a massive convoy of lipids into the phagophore. In this review, we present recent advances in our understanding of the intracellular membrane sources and lipid delivery mechanisms, which principally rely on vesicular transport and membrane contact sites that contribute to autophagosome biogenesis. In this context, we discuss lipid biosynthesis and lipid remodeling events that play a crucial role in both phagophore nucleation and expansion.

Originele taal-2English
Pagina's (van-tot)112-119
Aantal pagina's8
TijdschriftCurrent Opinion in Cell Biology
Volume71
Vroegere onlinedatum27-apr-2021
DOI's
StatusPublished - aug-2021

Citeer dit