Membrane transport of cobalamin

Mark Nijland, Jose M. Martínez Felices, Dirk J. Slotboom*, Chancievan Thangaratnarajah

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)

Samenvatting

A wide variety of organisms encode cobalamin-dependent enzymes catalyzing essential metabolic reactions, but the cofactor cobalamin (vitamin B12) is only synthesized by a subset of bacteria and archaea. The biosynthesis of cobalamin is complex and energetically costly, making cobalamin variants and precursors metabolically valuable. Auxotrophs for these molecules have evolved uptake mechanisms to compensate for the lack of a synthesis pathway. Bacterial transport of cobalamin involves the passage over one or two lipidic membranes in Gram-positive and -negative bacteria, respectively. In higher eukaryotes, a complex system of carriers, receptors and transporters facilitates the delivery of the essential molecule to the tissues. Biochemical and genetic approaches have identified different transporter families involved in cobalamin transport. The majority of the characterized cobalamin transporters are active transport systems that belong to the ATP-binding cassette (ABC) superfamily of transporters. In this chapter, we describe the different cobalamin transport systems characterized to date that are present in bacteria and humans, as well as yet-to-be-identified transporters.

Originele taal-2English
TitelVitamins and Hormones
RedacteurenGerald Litwack
UitgeverijACADEMIC PRESS INC ELSEVIER SCIENCE
Hoofdstuk5
Pagina's121-148
Aantal pagina's28
DOI's
StatusPublished - 22-mrt.-2022

Publicatie series

NaamVitamins and Hormones
UitgeverijElsevier
Volume119
ISSN van geprinte versie0083-6729

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