Mesenchymal Stem Cells Contribute to Tumor Cell Proliferation by Direct Cell-Cell Contact Interactions

Berber D. Roorda, Arja ter Elst, Tiny G. J. Meeuwsen-de Boer, Willem A. Kamps, Eveline S. J. M. de Bont*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

34 Citaten (Scopus)

Samenvatting

Bone marrow (BM)-derived mesenchymal stem cells (MSCs) have been implicated in tumor progression, making MSCs important targets for anti-cancer strategies. In this study, we show that MSCs promote tumor growth in vivo in a lymphoma xenograft model. We show that MSCs provide direct cell-cell contact interactions and, to a lesser extend, soluble factors that promote tumor cell proliferation and survival in vitro. PTK787/ZK 222584 reduces tumor growth-promoting effects of MSCs both in vitro and in vivo. Our results address the importance of targeting the MSCs for future anti-cancer strategies.

Originele taal-2English
Pagina's (van-tot)526-534
Aantal pagina's9
TijdschriftCancer Investigation
Volume28
Nummer van het tijdschrift5
DOI's
StatusPublished - jun-2010

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