Microbial vitamin production mediates dietary effects on diabetic risk

Daoming Wang, Van T. Pham, Robert E. Steinert, Alexandra Zhernakova, Jingyuan Fu*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

3 Citaten (Scopus)
124 Downloads (Pure)

Samenvatting

Adequate levels of essential vitamins are important for the prevention of diabetes. While the main efforts to address this are currently focused on the intake of vitamin supplements, improving and maintaining intrinsic vitamin production capacity, which is determined by gut microbes, has received insufficient attention. In this study, we systematically investigated the relationship between gut microbial vitamin production and factors related to diabetes and cardiometabolic health in a deeply phenotyped cohort, Lifelines-DEEP (N = 1,135). We found that blood glucose-related factors, lipids, circulating inflammation, and fecal short-chain fatty acids are associated with gut microbial vitamin production. Use of laxatives and metformin are associated with increased levels of vitamin B1/B6 biosynthesis pathways. We further reveal a mediatory role for microbial vitamin B1/B2 production on the influence of fruit intake on diabetes risk. This study provides preliminary evidence for microbiome-targeted vitamin metabolism interventions to promote health.

Originele taal-2English
Artikelnummer2154550
Aantal pagina's12
TijdschriftGut Microbes
Volume14
Nummer van het tijdschrift1
DOI's
StatusPublished - 6-dec.-2022

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