Microbiome to Brain: Unravelling the Multidirectional Axes of Communication

Sahar El Aidy, Roman Stilling, Timothy G. Dinan, John F. Cryan*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

47 Citaten (Scopus)
533 Downloads (Pure)

Samenvatting

The gut microbiome plays a crucial role in host physiology. Disruption of its community structure and function can have wide-ranging effects making it critical to understand exactly how the interactive dialogue between the host and its microbiota is regulated to maintain homeostasis. An array of multidirectional signalling molecules is clearly involved in the host-microbiome communication. This interactive signalling not only impacts the gastrointestinal tract, where the majority of microbiota resides, but also extends to affect other host systems including the brain and liver as well as the microbiome itself. Understanding the mechanistic principles of this inter-kingdom signalling is fundamental to unravelling how our supraorganism function to maintain wellbeing, subsequently opening up new avenues for microbiome manipulation to favour desirable mental health outcome.

Originele taal-2English
TitelMicrobial Endocrinology
SubtitelInterkingdom Signalling in Infectious Diseases and Health
RedacteurenMark Lyte
UitgeverijSpringer International Publishing AG
Pagina's301-336
Aantal pagina's36
Volume874
Uitgave2
ISBN van elektronische versie978-3-319-20215-0
ISBN van geprinte versie978-3-319-20214-3
DOI's
StatusPublished - 2016

Publicatie series

NaamAdvances in Experimental Medicine and Biology
UitgeverijSPRINGER INTERNATIONAL PUBLISHING AG
Volume874
ISSN van geprinte versie0065-2598

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