TY - JOUR
T1 - Microplastic and plastic pollution
T2 - impact on respiratory disease and health
AU - Vasse, Gwenda F
AU - Melgert, Barbro N
N1 - Copyright ©The authors 2024.
PY - 2024/4
Y1 - 2024/4
N2 - Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals and particles known as micro- and nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected in different locations of the human body, including in our lungs. This is likely a consequence of MNP exposure through the air we breathe. Yet, we still lack a comprehensive understanding of the impact that MNP exposure may have on respiratory disease and health. In this review, we have collated the current body of evidence on the implications of MNP inhalation on human lung health from
in vitro,
in vivo and occupational exposure studies. We focused on interactions between MNP pollution and different specific lung-resident cells and respiratory diseases. We conclude that it is evident that MNPs possess the capacity to affect lung tissue in disease and health. Yet, it remains unclear to which extent this occurs upon exposure to ambient levels of MNPs, emphasising the need for a more comprehensive evaluation of environmental MNP exposure levels in everyday life.
AB - Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals and particles known as micro- and nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected in different locations of the human body, including in our lungs. This is likely a consequence of MNP exposure through the air we breathe. Yet, we still lack a comprehensive understanding of the impact that MNP exposure may have on respiratory disease and health. In this review, we have collated the current body of evidence on the implications of MNP inhalation on human lung health from
in vitro,
in vivo and occupational exposure studies. We focused on interactions between MNP pollution and different specific lung-resident cells and respiratory diseases. We conclude that it is evident that MNPs possess the capacity to affect lung tissue in disease and health. Yet, it remains unclear to which extent this occurs upon exposure to ambient levels of MNPs, emphasising the need for a more comprehensive evaluation of environmental MNP exposure levels in everyday life.
KW - Humans
KW - Microplastics/adverse effects
KW - Inhalation Exposure/adverse effects
KW - Animals
KW - Lung/drug effects
KW - Respiratory Tract Diseases/chemically induced
KW - Risk Assessment
KW - Air Pollutants/adverse effects
KW - Risk Factors
KW - Plastics/adverse effects
KW - Occupational Exposure/adverse effects
U2 - 10.1183/16000617.0226-2023
DO - 10.1183/16000617.0226-2023
M3 - Review article
C2 - 39009408
SN - 0905-9180
VL - 33
JO - European respiratory review : an official journal of the European Respiratory Society
JF - European respiratory review : an official journal of the European Respiratory Society
IS - 172
M1 - 230226
ER -