MicroRNAs in hematopoietic stem cell aging

Daniëlle Gaby Luinenburg, Gerald de Haan*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)
22 Downloads (Pure)

Samenvatting

The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.

Originele taal-2English
Artikelnummer111281
Aantal pagina's5
TijdschriftMechanisms of Ageing and Development
Volume189
DOI's
StatusPublished - jul-2020

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