Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Xinghong Zhao, Zhibo Li, Oscar P Kuipers*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

13 Citaten (Scopus)
107 Downloads (Pure)


Zhao et al. describe a strategy to synthesize mimics of the recently discovered antimicrobial non-ribosomal peptide, brevicidine. The engineered mimics show antimicrobial activities against pathogens susceptible to brevicidine, which demonstrate that conversion of NRPs to RiPPs is feasible and offer great opportunities for engineering a wide range of effective antibiotics.

Originele taal-2English
Pagina's (van-tot)1262-1271
Aantal pagina's10
TijdschriftCell Chemical Biology
Nummer van het tijdschrift10
Vroegere onlinedatum19-jul.-2020
StatusPublished - 15-okt.-2020

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