Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Sebastien Jacquemont; Alexandre Reymond; Flore Zufferey; Louise Harewood; Robin G. Walters; Zoltan Kutalik; Danielle Martinet; Yiping Shen; Armand Valsesia; Noam D. Beckmann; Gudmar Thorleifsson; Marco Belfiore; Sonia Bouquillon; Dominique Campion; Nicole de Leeuw; Bert B. A. de Vries; Tonu Esko; Bridget A. Fernandez; Fernando Fernandez-Aranda; Jose Manuel Fernandez-Real; Monica Gratacos; Audrey Guilmatre; Juliane Hoyer; Marjo-Riitta Jarvelin; R. Frank Kooy; Ants Kurg; Cedric Le Caignec; Katrin Maennik; Orah S. Platt; Damien Sanlaville; Mieke M. Van Haelst; Sergi Villatoro Gomez; Faida Walha; Bai-lin Wu; Yongguo Yu; Azzedine Aboura; Marie-Claude Addor; Yves Alembik; Stylianos E. Antonarakis; Benoit Arveiler; Magalie Barth; Nathalie Bednarek; Frederique Bena; Sven Bergmann; Mylene Beri; Laura Bernardini; Bettina Blaumeiser; Dominique Bonneau; Armand Bottani; Odile Boute; Han G. Brunner; Dorothee Cailley; Patrick Callier; Jean Chiesa; Jacqueline Chrast; Lachlan Coin; Charles Coutton; Jean-Marie Cuisset; Jean-Christophe Cuvellier; Albert David; Benedicte de Freminville; Bruno Delobel; Marie-Ange Delrue; Benedicte Demeer; Dominique Descamps; Gerard Didelot; Klaus Dieterich; Vittoria Disciglio; Martine Doco-Fenzy; Severine Drunat; Benedicte Duban-Bedu; Christele Dubourg; Julia S. El-Sayed Moustafa; Paul Elliott; Brigitte H. W. Faas; Laurence Faivre; Anne Faudet; Florence Fellmann; Alessandra Ferrarini; Richard Fisher; Elisabeth Flori; Lukas Forer; Dominique Gaillard; Marion Gerard; Christian Gieger; Stefania Gimelli; Giorgio Gimelli; Hans J. Grabe; Agnes Guichet; Olivier Guillin; Anna-Liisa Hartikainen; Delphine Heron; Loyse Hippolyte; Muriel Holder; Georg Homuth; Bertrand Isidor; Sylvie Jaillard; Zdenek Jaros; Susana Jimenez-Murcia; Geraldine Joly Helas; Philippe Jonveaux; Satu Kaksonen; Boris Keren; Anita Kloss-Brandstaetter; Nine V. A. M. Knoers; David A. Koolen; Peter M. Kroisel; Florian Kronenberg; Audrey Labalme; Emilie Landais; Elisabetta Lapi; Valerie Layet; Solenn Legallic; Bruno Leheup; Barbara Leube; Suzanne Lewis; Josette Lucas; Kay D. MacDermot; Pall Magnusson; Christian Marshall; Michele Mathieu-Dramard; Mark I. McCarthy; Thomas Meitinger; Maria Antonietta Mencarelli; Giuseppe Merla; Alexandre Moerman; Vincent Mooser; Fanny Morice-Picard; Mafalda Mucciolo; Matthias Nauck; Ndeye Coumba Ndiaye; Ann Nordgren; Laurent Pasquier; Florence Petit; Rolph Pfundt; Ghislaine Plessis; Evica Rajcan-Separovic; Gian Paolo Ramelli; Anita Rauch; Roberto Ravazzolo; Andre Reis; Alessandra Renieri; Cristobal Richart; Janina S. Ried; Claudine Rieubland; Wendy Roberts; Katharina M. Roetzer; Caroline Rooryck; Massimiliano Rossi; Evald Saemundsen; Veronique Satre; Claudia Schurmann; Engilbert Sigurdsson; Dimitri J. Stavropoulos; Hreinn Stefansson; Carola Tengstrom; Unnur Thorsteinsdottir; Francisco J. Tinahones; Renaud Touraine; Louis Vallee; Ellen van Binsbergen; Nathalie Van der Aa; Catherine Vincent-Delorme; Sophie Visvikis-Siest; Peter Vollenweider; Henry Voelzke; Anneke T. Vulto-van Silfhout; Gerard Waeber; Carina Wallgren-Pettersson; Robert M. Witwicki; Simon Zwolinksi; Joris Andrieux; Xavier Estivill; James F. Gusella; Omar Gustafsson; Andres Metspalu; Stephen W. Scherer; Kari Stefansson; Alexandra I. F. Blakemore; Jacques S. Beckmann; Philippe Froguel

doi:10.1038/nature10406

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Sebastien Jacquemont, Alexandre Reymond, Flore Zufferey, Louise Harewood, Robin G. Walters, Zoltan Kutalik, Danielle Martinet, Yiping Shen, Armand Valsesia, Noam D. Beckmann, Gudmar Thorleifsson, Marco Belfiore, Sonia Bouquillon, Dominique Campion, Nicole de Leeuw, Bert B. A. de Vries, Tonu Esko, Bridget A. Fernandez, Fernando Fernandez-Aranda, Jose Manuel Fernandez-RealMonica Gratacos, Audrey Guilmatre, Juliane Hoyer, Marjo-Riitta Jarvelin, R. Frank Kooy, Ants Kurg, Cedric Le Caignec, Katrin Maennik, Orah S. Platt, Damien Sanlaville, Mieke M. Van Haelst, Sergi Villatoro Gomez, Faida Walha, Bai-lin Wu, Yongguo Yu, Azzedine Aboura, Marie-Claude Addor, Yves Alembik, Stylianos E. Antonarakis, Benoit Arveiler, Magalie Barth, Nathalie Bednarek, Frederique Bena, Sven Bergmann, Mylene Beri, Laura Bernardini, Bettina Blaumeiser, Dominique Bonneau, Armand Bottani, Odile Boute, Han G. Brunner, Dorothee Cailley, Patrick Callier, Jean Chiesa, Jacqueline Chrast, Lachlan Coin, Charles Coutton, Jean-Marie Cuisset, Jean-Christophe Cuvellier, Albert David, Benedicte de Freminville, Bruno Delobel, Marie-Ange Delrue, Benedicte Demeer, Dominique Descamps, Gerard Didelot, Klaus Dieterich, Vittoria Disciglio, Martine Doco-Fenzy, Severine Drunat, Benedicte Duban-Bedu, Christele Dubourg, Julia S. El-Sayed Moustafa, Paul Elliott, Brigitte H. W. Faas, Laurence Faivre, Anne Faudet, Florence Fellmann, Alessandra Ferrarini, Richard Fisher, Elisabeth Flori, Lukas Forer, Dominique Gaillard, Marion Gerard, Christian Gieger, Stefania Gimelli, Giorgio Gimelli, Hans J. Grabe, Agnes Guichet, Olivier Guillin, Anna-Liisa Hartikainen, Delphine Heron, Loyse Hippolyte, Muriel Holder, Georg Homuth, Bertrand Isidor, Sylvie Jaillard, Zdenek Jaros, Susana Jimenez-Murcia, Geraldine Joly Helas, Philippe Jonveaux, Satu Kaksonen, Boris Keren, Anita Kloss-Brandstaetter, Nine V. A. M. Knoers, David A. Koolen, Peter M. Kroisel, Florian Kronenberg, Audrey Labalme, Emilie Landais, Elisabetta Lapi, Valerie Layet, Solenn Legallic, Bruno Leheup, Barbara Leube, Suzanne Lewis, Josette Lucas, Kay D. MacDermot, Pall Magnusson, Christian Marshall, Michele Mathieu-Dramard, Mark I. McCarthy, Thomas Meitinger, Maria Antonietta Mencarelli, Giuseppe Merla, Alexandre Moerman, Vincent Mooser, Fanny Morice-Picard, Mafalda Mucciolo, Matthias Nauck, Ndeye Coumba Ndiaye, Ann Nordgren, Laurent Pasquier, Florence Petit, Rolph Pfundt, Ghislaine Plessis, Evica Rajcan-Separovic, Gian Paolo Ramelli, Anita Rauch, Roberto Ravazzolo, Andre Reis, Alessandra Renieri, Cristobal Richart, Janina S. Ried, Claudine Rieubland, Wendy Roberts, Katharina M. Roetzer, Caroline Rooryck, Massimiliano Rossi, Evald Saemundsen, Veronique Satre, Claudia Schurmann, Engilbert Sigurdsson, Dimitri J. Stavropoulos, Hreinn Stefansson, Carola Tengstrom, Unnur Thorsteinsdottir, Francisco J. Tinahones, Renaud Touraine, Louis Vallee, Ellen van Binsbergen, Nathalie Van der Aa, Catherine Vincent-Delorme, Sophie Visvikis-Siest, Peter Vollenweider, Henry Voelzke, Anneke T. Vulto-van Silfhout, Gerard Waeber, Carina Wallgren-Pettersson, Robert M. Witwicki, Simon Zwolinksi, Joris Andrieux, Xavier Estivill, James F. Gusella, Omar Gustafsson, Andres Metspalu, Stephen W. Scherer, Kari Stefansson, Alexandra I. F. Blakemore, Jacques S. Beckmann^*, Philippe Froguel

^*Corresponding author voor dit werk

Faculteit Medische Wetenschappen/UMCG

Onderzoeksoutput › Academic › peer review

380 Citaten (Scopus)

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Both obesity and being underweight have been associated with increased mortality(1,2). Underweight, defined as a body mass index (BMI)

Originele taal-2	English
Pagina's (van-tot)	97-U111
Aantal pagina's	8
Tijdschrift	Nature
Volume	478
DOI's	https://doi.org/10.1038/nature10406
Status	Published - 6-okt.-2011

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Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus
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Jacquemont, S., Reymond, A., Zufferey, F., Harewood, L., Walters, R. G., Kutalik, Z., Martinet, D., Shen, Y., Valsesia, A., Beckmann, N. D., Thorleifsson, G., Belfiore, M., Bouquillon, S., Campion, D., de Leeuw, N., de Vries, B. B. A., Esko, T., Fernandez, B. A., Fernandez-Aranda, F., ... Froguel, P. (2011). Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature, 478, 97-U111. https://doi.org/10.1038/nature10406

@article{9409d619b58642e89813c1be0af20a0a,

title = "Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus",

abstract = "Both obesity and being underweight have been associated with increased mortality(1,2). Underweight, defined as a body mass index (BMI)",

keywords = "COPY NUMBER VARIATION, BODY-MASS INDEX, DEPENDENT PROBE AMPLIFICATION, CIRCULAR BINARY SEGMENTATION, TIME QUANTITATIVE PCR, HIDDEN-MARKOV MODEL, SNP GENOTYPING DATA, FAILURE-TO-THRIVE, RELATIVE QUANTIFICATION, METABOLIC SYNDROME",

author = "Sebastien Jacquemont and Alexandre Reymond and Flore Zufferey and Louise Harewood and Walters, {Robin G.} and Zoltan Kutalik and Danielle Martinet and Yiping Shen and Armand Valsesia and Beckmann, {Noam D.} and Gudmar Thorleifsson and Marco Belfiore and Sonia Bouquillon and Dominique Campion and {de Leeuw}, Nicole and {de Vries}, {Bert B. A.} and Tonu Esko and Fernandez, {Bridget A.} and Fernando Fernandez-Aranda and {Manuel Fernandez-Real}, Jose and Monica Gratacos and Audrey Guilmatre and Juliane Hoyer and Marjo-Riitta Jarvelin and Kooy, {R. Frank} and Ants Kurg and {Le Caignec}, Cedric and Katrin Maennik and Platt, {Orah S.} and Damien Sanlaville and {Van Haelst}, {Mieke M.} and {Villatoro Gomez}, Sergi and Faida Walha and Bai-lin Wu and Yongguo Yu and Azzedine Aboura and Marie-Claude Addor and Yves Alembik and Antonarakis, {Stylianos E.} and Benoit Arveiler and Magalie Barth and Nathalie Bednarek and Frederique Bena and Sven Bergmann and Mylene Beri and Laura Bernardini and Bettina Blaumeiser and Dominique Bonneau and Armand Bottani and Odile Boute and Brunner, {Han G.} and Dorothee Cailley and Patrick Callier and Jean Chiesa and Jacqueline Chrast and Lachlan Coin and Charles Coutton and Jean-Marie Cuisset and Jean-Christophe Cuvellier and Albert David and {de Freminville}, Benedicte and Bruno Delobel and Marie-Ange Delrue and Benedicte Demeer and Dominique Descamps and Gerard Didelot and Klaus Dieterich and Vittoria Disciglio and Martine Doco-Fenzy and Severine Drunat and Benedicte Duban-Bedu and Christele Dubourg and Moustafa, {Julia S. El-Sayed} and Paul Elliott and Faas, {Brigitte H. W.} and Laurence Faivre and Anne Faudet and Florence Fellmann and Alessandra Ferrarini and Richard Fisher and Elisabeth Flori and Lukas Forer and Dominique Gaillard and Marion Gerard and Christian Gieger and Stefania Gimelli and Giorgio Gimelli and Grabe, {Hans J.} and Agnes Guichet and Olivier Guillin and Anna-Liisa Hartikainen and Delphine Heron and Loyse Hippolyte and Muriel Holder and Georg Homuth and Bertrand Isidor and Sylvie Jaillard and Zdenek Jaros and Susana Jimenez-Murcia and Helas, {Geraldine Joly} and Philippe Jonveaux and Satu Kaksonen and Boris Keren and Anita Kloss-Brandstaetter and Knoers, {Nine V. A. M.} and Koolen, {David A.} and Kroisel, {Peter M.} and Florian Kronenberg and Audrey Labalme and Emilie Landais and Elisabetta Lapi and Valerie Layet and Solenn Legallic and Bruno Leheup and Barbara Leube and Suzanne Lewis and Josette Lucas and MacDermot, {Kay D.} and Pall Magnusson and Christian Marshall and Michele Mathieu-Dramard and McCarthy, {Mark I.} and Thomas Meitinger and Mencarelli, {Maria Antonietta} and Giuseppe Merla and Alexandre Moerman and Vincent Mooser and Fanny Morice-Picard and Mafalda Mucciolo and Matthias Nauck and Ndiaye, {Ndeye Coumba} and Ann Nordgren and Laurent Pasquier and Florence Petit and Rolph Pfundt and Ghislaine Plessis and Evica Rajcan-Separovic and Ramelli, {Gian Paolo} and Anita Rauch and Roberto Ravazzolo and Andre Reis and Alessandra Renieri and Cristobal Richart and Ried, {Janina S.} and Claudine Rieubland and Wendy Roberts and Roetzer, {Katharina M.} and Caroline Rooryck and Massimiliano Rossi and Evald Saemundsen and Veronique Satre and Claudia Schurmann and Engilbert Sigurdsson and Stavropoulos, {Dimitri J.} and Hreinn Stefansson and Carola Tengstrom and Unnur Thorsteinsdottir and Tinahones, {Francisco J.} and Renaud Touraine and Louis Vallee and {van Binsbergen}, Ellen and {Van der Aa}, Nathalie and Catherine Vincent-Delorme and Sophie Visvikis-Siest and Peter Vollenweider and Henry Voelzke and {Vulto-van Silfhout}, {Anneke T.} and Gerard Waeber and Carina Wallgren-Pettersson and Witwicki, {Robert M.} and Simon Zwolinksi and Joris Andrieux and Xavier Estivill and Gusella, {James F.} and Omar Gustafsson and Andres Metspalu and Scherer, {Stephen W.} and Kari Stefansson and Blakemore, {Alexandra I. F.} and Beckmann, {Jacques S.} and Philippe Froguel",

year = "2011",

month = oct,

day = "6",

doi = "10.1038/nature10406",

language = "English",

volume = "478",

pages = "97--U111",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

}

Jacquemont, S, Reymond, A, Zufferey, F, Harewood, L, Walters, RG, Kutalik, Z, Martinet, D, Shen, Y, Valsesia, A, Beckmann, ND, Thorleifsson, G, Belfiore, M, Bouquillon, S, Campion, D, de Leeuw, N, de Vries, BBA, Esko, T, Fernandez, BA, Fernandez-Aranda, F, Manuel Fernandez-Real, J, Gratacos, M, Guilmatre, A, Hoyer, J, Jarvelin, M-R, Kooy, RF, Kurg, A, Le Caignec, C, Maennik, K, Platt, OS, Sanlaville, D, Van Haelst, MM, Villatoro Gomez, S, Walha, F, Wu, B, Yu, Y, Aboura, A, Addor, M-C, Alembik, Y, Antonarakis, SE, Arveiler, B, Barth, M, Bednarek, N, Bena, F, Bergmann, S, Beri, M, Bernardini, L, Blaumeiser, B, Bonneau, D, Bottani, A, Boute, O, Brunner, HG, Cailley, D, Callier, P, Chiesa, J, Chrast, J, Coin, L, Coutton, C, Cuisset, J-M, Cuvellier, J-C, David, A, de Freminville, B, Delobel, B, Delrue, M-A, Demeer, B, Descamps, D, Didelot, G, Dieterich, K, Disciglio, V, Doco-Fenzy, M, Drunat, S, Duban-Bedu, B, Dubourg, C, Moustafa, JSE-S, Elliott, P, Faas, BHW, Faivre, L, Faudet, A, Fellmann, F, Ferrarini, A, Fisher, R, Flori, E, Forer, L, Gaillard, D, Gerard, M, Gieger, C, Gimelli, S, Gimelli, G, Grabe, HJ, Guichet, A, Guillin, O, Hartikainen, A-L, Heron, D, Hippolyte, L, Holder, M, Homuth, G, Isidor, B, Jaillard, S, Jaros, Z, Jimenez-Murcia, S, Helas, GJ, Jonveaux, P, Kaksonen, S, Keren, B, Kloss-Brandstaetter, A, Knoers, NVAM, Koolen, DA, Kroisel, PM, Kronenberg, F, Labalme, A, Landais, E, Lapi, E, Layet, V, Legallic, S, Leheup, B, Leube, B, Lewis, S, Lucas, J, MacDermot, KD, Magnusson, P, Marshall, C, Mathieu-Dramard, M, McCarthy, MI, Meitinger, T, Mencarelli, MA, Merla, G, Moerman, A, Mooser, V, Morice-Picard, F, Mucciolo, M, Nauck, M, Ndiaye, NC, Nordgren, A, Pasquier, L, Petit, F, Pfundt, R, Plessis, G, Rajcan-Separovic, E, Ramelli, GP, Rauch, A, Ravazzolo, R, Reis, A, Renieri, A, Richart, C, Ried, JS, Rieubland, C, Roberts, W, Roetzer, KM, Rooryck, C, Rossi, M, Saemundsen, E, Satre, V, Schurmann, C, Sigurdsson, E, Stavropoulos, DJ, Stefansson, H, Tengstrom, C, Thorsteinsdottir, U, Tinahones, FJ, Touraine, R, Vallee, L, van Binsbergen, E, Van der Aa, N, Vincent-Delorme, C, Visvikis-Siest, S, Vollenweider, P, Voelzke, H, Vulto-van Silfhout, AT, Waeber, G, Wallgren-Pettersson, C, Witwicki, RM, Zwolinksi, S, Andrieux, J, Estivill, X, Gusella, JF, Gustafsson, O, Metspalu, A, Scherer, SW, Stefansson, K, Blakemore, AIF, Beckmann, JS & Froguel, P 2011, 'Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus', Nature, vol. 478, blz. 97-U111. https://doi.org/10.1038/nature10406

TY - JOUR

T1 - Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

AU - Jacquemont, Sebastien

AU - Reymond, Alexandre

AU - Zufferey, Flore

AU - Harewood, Louise

AU - Walters, Robin G.

AU - Kutalik, Zoltan

AU - Martinet, Danielle

AU - Shen, Yiping

AU - Valsesia, Armand

AU - Beckmann, Noam D.

AU - Thorleifsson, Gudmar

AU - Belfiore, Marco

AU - Bouquillon, Sonia

AU - Campion, Dominique

AU - de Leeuw, Nicole

AU - de Vries, Bert B. A.

AU - Esko, Tonu

AU - Fernandez, Bridget A.

AU - Fernandez-Aranda, Fernando

AU - Manuel Fernandez-Real, Jose

AU - Gratacos, Monica

AU - Guilmatre, Audrey

AU - Hoyer, Juliane

AU - Jarvelin, Marjo-Riitta

AU - Kooy, R. Frank

AU - Kurg, Ants

AU - Le Caignec, Cedric

AU - Maennik, Katrin

AU - Platt, Orah S.

AU - Sanlaville, Damien

AU - Van Haelst, Mieke M.

AU - Villatoro Gomez, Sergi

AU - Walha, Faida

AU - Wu, Bai-lin

AU - Yu, Yongguo

AU - Aboura, Azzedine

AU - Addor, Marie-Claude

AU - Alembik, Yves

AU - Antonarakis, Stylianos E.

AU - Arveiler, Benoit

AU - Barth, Magalie

AU - Bednarek, Nathalie

AU - Bena, Frederique

AU - Bergmann, Sven

AU - Beri, Mylene

AU - Bernardini, Laura

AU - Blaumeiser, Bettina

AU - Bonneau, Dominique

AU - Bottani, Armand

AU - Boute, Odile

AU - Brunner, Han G.

AU - Cailley, Dorothee

AU - Callier, Patrick

AU - Chiesa, Jean

AU - Chrast, Jacqueline

AU - Coin, Lachlan

AU - Coutton, Charles

AU - Cuisset, Jean-Marie

AU - Cuvellier, Jean-Christophe

AU - David, Albert

AU - de Freminville, Benedicte

AU - Delobel, Bruno

AU - Delrue, Marie-Ange

AU - Demeer, Benedicte

AU - Descamps, Dominique

AU - Didelot, Gerard

AU - Dieterich, Klaus

AU - Disciglio, Vittoria

AU - Doco-Fenzy, Martine

AU - Drunat, Severine

AU - Duban-Bedu, Benedicte

AU - Dubourg, Christele

AU - Moustafa, Julia S. El-Sayed

AU - Elliott, Paul

AU - Faas, Brigitte H. W.

AU - Faivre, Laurence

AU - Faudet, Anne

AU - Fellmann, Florence

AU - Ferrarini, Alessandra

AU - Fisher, Richard

AU - Flori, Elisabeth

AU - Forer, Lukas

AU - Gaillard, Dominique

AU - Gerard, Marion

AU - Gieger, Christian

AU - Gimelli, Stefania

AU - Gimelli, Giorgio

AU - Grabe, Hans J.

AU - Guichet, Agnes

AU - Guillin, Olivier

AU - Hartikainen, Anna-Liisa

AU - Heron, Delphine

AU - Hippolyte, Loyse

AU - Holder, Muriel

AU - Homuth, Georg

AU - Isidor, Bertrand

AU - Jaillard, Sylvie

AU - Jaros, Zdenek

AU - Jimenez-Murcia, Susana

AU - Helas, Geraldine Joly

AU - Jonveaux, Philippe

AU - Kaksonen, Satu

AU - Keren, Boris

AU - Kloss-Brandstaetter, Anita

AU - Knoers, Nine V. A. M.

AU - Koolen, David A.

AU - Kroisel, Peter M.

AU - Kronenberg, Florian

AU - Labalme, Audrey

AU - Landais, Emilie

AU - Lapi, Elisabetta

AU - Layet, Valerie

AU - Legallic, Solenn

AU - Leheup, Bruno

AU - Leube, Barbara

AU - Lewis, Suzanne

AU - Lucas, Josette

AU - MacDermot, Kay D.

AU - Magnusson, Pall

AU - Marshall, Christian

AU - Mathieu-Dramard, Michele

AU - McCarthy, Mark I.

AU - Meitinger, Thomas

AU - Mencarelli, Maria Antonietta

AU - Merla, Giuseppe

AU - Moerman, Alexandre

AU - Mooser, Vincent

AU - Morice-Picard, Fanny

AU - Mucciolo, Mafalda

AU - Nauck, Matthias

AU - Ndiaye, Ndeye Coumba

AU - Nordgren, Ann

AU - Pasquier, Laurent

AU - Petit, Florence

AU - Pfundt, Rolph

AU - Plessis, Ghislaine

AU - Rajcan-Separovic, Evica

AU - Ramelli, Gian Paolo

AU - Rauch, Anita

AU - Ravazzolo, Roberto

AU - Reis, Andre

AU - Renieri, Alessandra

AU - Richart, Cristobal

AU - Ried, Janina S.

AU - Rieubland, Claudine

AU - Roberts, Wendy

AU - Roetzer, Katharina M.

AU - Rooryck, Caroline

AU - Rossi, Massimiliano

AU - Saemundsen, Evald

AU - Satre, Veronique

AU - Schurmann, Claudia

AU - Sigurdsson, Engilbert

AU - Stavropoulos, Dimitri J.

AU - Stefansson, Hreinn

AU - Tengstrom, Carola

AU - Thorsteinsdottir, Unnur

AU - Tinahones, Francisco J.

AU - Touraine, Renaud

AU - Vallee, Louis

AU - van Binsbergen, Ellen

AU - Van der Aa, Nathalie

AU - Vincent-Delorme, Catherine

AU - Visvikis-Siest, Sophie

AU - Vollenweider, Peter

AU - Voelzke, Henry

AU - Vulto-van Silfhout, Anneke T.

AU - Waeber, Gerard

AU - Wallgren-Pettersson, Carina

AU - Witwicki, Robert M.

AU - Zwolinksi, Simon

AU - Andrieux, Joris

AU - Estivill, Xavier

AU - Gusella, James F.

AU - Gustafsson, Omar

AU - Metspalu, Andres

AU - Scherer, Stephen W.

AU - Stefansson, Kari

AU - Blakemore, Alexandra I. F.

AU - Beckmann, Jacques S.

AU - Froguel, Philippe

PY - 2011/10/6

Y1 - 2011/10/6

N2 - Both obesity and being underweight have been associated with increased mortality(1,2). Underweight, defined as a body mass index (BMI)

AB - Both obesity and being underweight have been associated with increased mortality(1,2). Underweight, defined as a body mass index (BMI)

KW - COPY NUMBER VARIATION

KW - BODY-MASS INDEX

KW - DEPENDENT PROBE AMPLIFICATION

KW - CIRCULAR BINARY SEGMENTATION

KW - TIME QUANTITATIVE PCR

KW - HIDDEN-MARKOV MODEL

KW - SNP GENOTYPING DATA

KW - FAILURE-TO-THRIVE

KW - RELATIVE QUANTIFICATION

KW - METABOLIC SYNDROME

U2 - 10.1038/nature10406

DO - 10.1038/nature10406

M3 - Letter

SN - 0028-0836

VL - 478

SP - 97-U111

JO - Nature

JF - Nature

ER -

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

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