Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021

Artur J. Sabat; Erik Bathoorn; Monika A. Chlebowicz-Fliss; Viktoria Akkerboom; Inge Kamphuis; Claudy Oliveira Dos Santos; Alexander W. Friedrich

doi:10.2807/1560-7917.ES.2021.26.37.2100800

Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021

Artur J. Sabat, Erik Bathoorn, Monika A. Chlebowicz-Fliss, Viktoria Akkerboom, Inge Kamphuis, Claudy Oliveira Dos Santos, Alexander W. Friedrich^*

^*Corresponding author voor dit werk

Microbes in Health and Disease (MHD)

Onderzoeksoutput › Academic › peer review

4 Citaten (Scopus)

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We describe two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay. The isolates were recovered in late February and early March 2021 from two patients in different hospitals in the northern Netherlands. Variations between the two isolate genomes indicate that this MRSA strain might have been spreading for some time and could have disseminated to other regions of the Netherlands and other European countries.

Originele taal-2	English
Artikelnummer	2100800
Aantal pagina's	6
Tijdschrift	Eurosurveillance
Volume	26
Nummer van het tijdschrift	37
DOI's	https://doi.org/10.2807/1560-7917.ES.2021.26.37.2100800
Status	Published - 16-sep.-2021

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10.2807/1560-7917.ES.2021.26.37.2100800Licentie: CC BY

Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021Final publisher's version, 388 KBLicentie: CC BY

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title = "Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021",

abstract = "We describe two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay. The isolates were recovered in late February and early March 2021 from two patients in different hospitals in the northern Netherlands. Variations between the two isolate genomes indicate that this MRSA strain might have been spreading for some time and could have disseminated to other regions of the Netherlands and other European countries.",

keywords = "Europe, Humans, Methicillin, Methicillin-Resistant Staphylococcus aureus/genetics, Netherlands/epidemiology, Staphylococcal Infections/diagnosis",

author = "Sabat, {Artur J.} and Erik Bathoorn and Chlebowicz-Fliss, {Monika A.} and Viktoria Akkerboom and Inge Kamphuis and {Dos Santos}, {Claudy Oliveira} and Friedrich, {Alexander W.}",

year = "2021",

month = sep,

day = "16",

doi = "10.2807/1560-7917.ES.2021.26.37.2100800",

language = "English",

volume = "26",

journal = "Eurosurveillance",

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TY - JOUR

T1 - Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021

AU - Sabat, Artur J.

AU - Bathoorn, Erik

AU - Chlebowicz-Fliss, Monika A.

AU - Akkerboom, Viktoria

AU - Kamphuis, Inge

AU - Dos Santos, Claudy Oliveira

AU - Friedrich, Alexander W.

PY - 2021/9/16

Y1 - 2021/9/16

N2 - We describe two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay. The isolates were recovered in late February and early March 2021 from two patients in different hospitals in the northern Netherlands. Variations between the two isolate genomes indicate that this MRSA strain might have been spreading for some time and could have disseminated to other regions of the Netherlands and other European countries.

AB - We describe two false-negative results in the detection of meticillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 and spa type t011 using the Cepheid Xpert MRSA NxG assay. The isolates were recovered in late February and early March 2021 from two patients in different hospitals in the northern Netherlands. Variations between the two isolate genomes indicate that this MRSA strain might have been spreading for some time and could have disseminated to other regions of the Netherlands and other European countries.

KW - Europe

KW - Humans

KW - Methicillin

KW - Methicillin-Resistant Staphylococcus aureus/genetics

KW - Netherlands/epidemiology

KW - Staphylococcal Infections/diagnosis

U2 - 10.2807/1560-7917.ES.2021.26.37.2100800

DO - 10.2807/1560-7917.ES.2021.26.37.2100800

M3 - Article

C2 - 34533121

SN - 1560-7917

VL - 26

JO - Eurosurveillance

JF - Eurosurveillance

IS - 37

M1 - 2100800

ER -

Misidentification of meticillin-resistant Staphylococcus aureus by the Cepheid Xpert MRSA NxG assay, the Netherlands, February to March 2021

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