Mitochondrial epigenetics: an overlooked layer of regulation?

Monique G. P. van der Wijst; Marianne G. Rots

doi:10.1016/j.tig.2015.03.009

Mitochondrial epigenetics: an overlooked layer of regulation?

Monique G. P. van der Wijst, Marianne G. Rots^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

54 Citaten (Scopus)

Samenvatting

Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

Originele taal-2	English
Pagina's (van-tot)	353-356
Aantal pagina's	4
Tijdschrift	Trends in Genetics
Volume	31
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1016/j.tig.2015.03.009
Status	Published - jul-2015

Toegang tot document

10.1016/j.tig.2015.03.009

Citeer dit

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title = "Mitochondrial epigenetics: an overlooked layer of regulation?",

abstract = "Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.",

keywords = "mitochondrial epigenetics, mitoepigenetics, DNA methylation, DNA hydroxymethylation, mtDNMT1, mtDNA, DNA, METHYLATION, TRANSCRIPTION, DISEASE, SHOWS",

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year = "2015",

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AU - Rots, Marianne G.

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N2 - Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

AB - Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.

KW - mitochondrial epigenetics

KW - mitoepigenetics

KW - DNA methylation

KW - DNA hydroxymethylation

KW - mtDNMT1

KW - mtDNA

KW - DNA

KW - METHYLATION

KW - TRANSCRIPTION

KW - DISEASE

KW - SHOWS

U2 - 10.1016/j.tig.2015.03.009

DO - 10.1016/j.tig.2015.03.009

M3 - Editorial

VL - 31

SP - 353

EP - 356

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

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