TY - JOUR
T1 - Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis
T2 - a report of four cases and a systematic review of the literature
AU - Bouma, Wobbe
AU - Klinkenberg, Theo J.
AU - van der Horst, Iwan C. C.
AU - Wijdh-den Hamer, Inez J.
AU - Erasmus, Michiel E.
AU - Bijl, Marc
AU - Suurmeijer, Albert J. H.
AU - Zijlstra, Felix
AU - Mariani, Massimo A.
PY - 2010/3/23
Y1 - 2010/3/23
N2 - Libman-Sacks endocarditis of the mitral valve was first described by Libman and Sacks in 1924. Currently, the sterile verrucous vegetative lesions seen in Libman-Sacks endocarditis are regarded as a cardiac manifestation of both systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asymptomatic, complications of Libman-Sacks endocarditis may include superimposed bacterial endocarditis, thromboembolic events, and severe valvular regurgitation and/or stenosis requiring surgery. In this study we report two cases of mitral valve repair and two cases of mitral valve replacement for mitral regurgitation (MR) caused by Libman-Sacks endocarditis. In addition, we provide a systematic review of the English literature on mitral valve surgery for MR caused by Libman-Sacks endocarditis. This report shows that mitral valve repair is feasible and effective in young patients with relatively stable SLE and/or APS and only localized mitral valve abnormalities caused by Libman-Sacks endocarditis. Both clinical and echocardiographic follow-up after repair show excellent mid-and long-term results.
AB - Libman-Sacks endocarditis of the mitral valve was first described by Libman and Sacks in 1924. Currently, the sterile verrucous vegetative lesions seen in Libman-Sacks endocarditis are regarded as a cardiac manifestation of both systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS). Although typically mild and asymptomatic, complications of Libman-Sacks endocarditis may include superimposed bacterial endocarditis, thromboembolic events, and severe valvular regurgitation and/or stenosis requiring surgery. In this study we report two cases of mitral valve repair and two cases of mitral valve replacement for mitral regurgitation (MR) caused by Libman-Sacks endocarditis. In addition, we provide a systematic review of the English literature on mitral valve surgery for MR caused by Libman-Sacks endocarditis. This report shows that mitral valve repair is feasible and effective in young patients with relatively stable SLE and/or APS and only localized mitral valve abnormalities caused by Libman-Sacks endocarditis. Both clinical and echocardiographic follow-up after repair show excellent mid-and long-term results.
KW - PRIMARY ANTIPHOSPHOLIPID SYNDROME
KW - VALVULAR HEART-DISEASE
KW - RUPTURED CHORDAE TENDINEAE
KW - LUPUS-ERYTHEMATOSUS
KW - TRANSESOPHAGEAL ECHOCARDIOGRAPHY
KW - CARDIOVASCULAR MANIFESTATIONS
KW - REPLACEMENT
KW - ANTIBODIES
KW - DIAGNOSIS
KW - INVOLVEMENT
U2 - 10.1186/1749-8090-5-13
DO - 10.1186/1749-8090-5-13
M3 - Review article
SN - 1749-8090
VL - 5
JO - Journal of cardiothoracic surgery
JF - Journal of cardiothoracic surgery
M1 - 13
ER -