MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen, Lisa M Coussens

Onderzoeksoutputpeer review

139 Citaten (Scopus)


Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Originele taal-2English
Pagina's (van-tot)251-252
Aantal pagina's2
TijdschriftCancer cell
Nummer van het tijdschrift4
StatusPublished - okt.-2002
Extern gepubliceerdJa

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