MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen; Lisa M Coussens

doi:10.1016/s1535-6108(02)00157-5

MMP9 potentiates pulmonary metastasis formation

Léon C L van Kempen, Lisa M Coussens

Onderzoeksoutput › peer review

139 Citaten (Scopus)

Samenvatting

Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

Originele taal-2	English
Pagina's (van-tot)	251-252
Aantal pagina's	2
Tijdschrift	Cancer cell
Volume	2
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/s1535-6108(02)00157-5
Status	Published - okt.-2002
Extern gepubliceerd	Ja

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title = "MMP9 potentiates pulmonary metastasis formation",

abstract = "Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).",

keywords = "Animals, Disease Progression, Humans, Liver/blood supply, Lung Neoplasms/metabolism, Macrophages/enzymology, Matrix Metalloproteinase 9/physiology, Precancerous Conditions, Vascular Endothelial Growth Factor Receptor-1/metabolism",

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AU - van Kempen, Léon C L

AU - Coussens, Lisa M

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AB - Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

KW - Animals

KW - Disease Progression

KW - Humans

KW - Liver/blood supply

KW - Lung Neoplasms/metabolism

KW - Macrophages/enzymology

KW - Matrix Metalloproteinase 9/physiology

KW - Precancerous Conditions

KW - Vascular Endothelial Growth Factor Receptor-1/metabolism

U2 - 10.1016/s1535-6108(02)00157-5

DO - 10.1016/s1535-6108(02)00157-5

M3 - Review article

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JO - Cancer cell

JF - Cancer cell

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