Mobilization of hematopoietic stem and progenitor cells in mice

Simon N Robinson, Ronald P van Os

OnderzoeksoutputAcademic

1 Citaat (Scopus)

Samenvatting

Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental 'niche' (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.

Originele taal-2English
TitelMethods in Molecular Biology
SubtitelHematopoietic Stem Cell Protocols
RedacteurenKevin Bunting
UitgeverijHumana Press
Pagina's31-53
Aantal pagina's23
Volume430
UitgaveIII
ISBN van geprinte versie1064-3745
DOI's
StatusPublished - 2008

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