Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes

Antonie J. van der Zouwen, Martin D. Witte*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

3 Citaten (Scopus)
59 Downloads (Pure)


Combinatorial and modular methods to synthesize small molecule modulators of protein activity have proven to be powerful tools in the development of new drug-like molecules. Over the past decade, these methodologies have been adapted toward utilization in the development of activity- and affinity-based chemical probes, as well as in chemoproteomic profiling. In this review, we will discuss how methods like multicomponent reactions, DNA-encoded libraries, phage displays, and others provide new ways to rapidly screen novel chemical probes against proteins of interest.

Originele taal-2English
Aantal pagina's17
TijdschriftFrontiers in Chemistry
StatusPublished - 15-apr-2021

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