Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease

Rutger A. F. Gjaltema, Ruud A. Bank*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

111 Citaten (Scopus)
555 Downloads (Pure)


Collagen is a macromolecule that has versatile roles in physiology, ranging from structural support to mediating cell signaling. Formation of mature collagen fibrils out of procollagen -chains requires a variety of enzymes and chaperones in a complex process spanning both intracellular and extracellular post-translational modifications. These processes include modifications of amino acids, folding of procollagen -chains into a triple-helical configuration and subsequent stabilization, facilitation of transportation out of the cell, cleavage of propeptides, aggregation, cross-link formation, and finally the formation of mature fibrils. Disruption of any of the proteins involved in these biosynthesis steps potentially result in a variety of connective tissue diseases because of a destabilized extracellular matrix. In this review, we give a revised overview of the enzymes and chaperones currently known to be relevant to the conversion of lysine and proline into hydroxyproline and hydroxylysine, respectively, and the O-glycosylation of hydroxylysine and give insights into the consequences when these steps are disrupted.

Originele taal-2English
Pagina's (van-tot)74-95
Aantal pagina's22
TijdschriftCritical reviews in biochemistry and molecular biology
Nummer van het tijdschrift1
StatusPublished - 2017

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