Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Casper Kierulf-Lassen*, Gertrude J. Nieuwenhuijs-Moeke, Nicoline V. Krogstrup, Mihai Oltean, Bente Jespersen, Frank J. M. F. Dor

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    21 Citaten (Scopus)

    Samenvatting

    Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized. (C) 2015 S. Karger AG, Basel

    Originele taal-2English
    Pagina's (van-tot)151-183
    Aantal pagina's33
    TijdschriftEuropean surgical research
    Volume55
    Nummer van het tijdschrift3
    DOI's
    StatusPublished - 2015

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