@inbook{953ceb11e8be40ed99ca7f4b17d1ebaf,
title = "Monitoring during and after tuberculosis treatment.",
abstract = "TB treatment is long and often complicated by adverse reactions. Baseline assessment can reduce the likelihood of adverse reactions, especially DILI. Regular monitoring can ensure treatment efficacy and prevent serious complications. A slow response to treatment may indicate poor adherence, an inadequate treatment regimen or acquired drug resistance. Adherence can be addressed by the use of directly observed therapy in a supportive environment. To avoid under- and overdosing, plasma drug concentrations can be measured to tailor the dose to the individual needs of a patient (i.e. TDM). To assess treatment response, the 2-month sputum test is an important time-point for decision making during treatment. Confirmation of treatment response at the end of treatment and the absence of relapse over at least the ensuing 12 months is essential to determine cure. To conclude, monitoring at the start, during and after TB treatment is a simple but necessary task for the TB team to ensure the optimal course and outcome of TB treatment.",
author = "Jan-Willem Alffenaar and Onno Akkerman and Graham Bothamley",
year = "2018",
month = dec,
day = "1",
doi = "10.1183/2312508X.10022217",
language = "English",
series = "ERS Monograph",
pages = "308--326",
booktitle = "Tuberculosis",
}